TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
TI  - Metabolic Profiles of Obesity in American Indians: The Strong Heart Family Study
SN  - 1932-6203
PY  - 2016///
KW  - *Indians, North American
KW  - *Metabolome
KW  - *Obesity/bl [Blood]
KW  - *Obesity/eh [Ethnology]
KW  - Adolescent
KW  - Adult
KW  - Amino Acids/bl [Blood]
KW  - Blood Glucose/me [Metabolism]
KW  - Body Mass Index
KW  - Chromatography, Liquid
KW  - Databases, Factual
KW  - Fasting
KW  - Female
KW  - Humans
KW  - Insulin Resistance
KW  - Male
KW  - Mass Spectrometry
KW  - Metabolomics/mt [Methods]
KW  - Middle Aged
KW  - Obesity/di [Diagnosis]
KW  - Obesity/pp [Physiopathology]
KW  - Peptides/bl [Blood]
KW  - Prospective Studies
KW  - Risk Factors
KW  - Sphingolipids/bl [Blood]
KW  - Steroids/bl [Blood]
KW  - United States
KW  - Waist Circumference
KW  - MedStar Health Research Institute
KW  - Journal Article
N1  - Available online through MWHC library: 2006 - present
N2  - Obesity is a typical metabolic disorder resulting from the imbalance between energy intake and expenditure. American Indians suffer disproportionately high rates of obesity and diabetes. The goal of this study is to identify metabolic profiles of obesity in 431 normoglycemic American Indians participating in the Strong Heart Family Study. Using an untargeted liquid chromatography-mass spectrometry, we detected 1,364 distinct m/z features matched to known compounds in the current metabolomics databases. We conducted multivariate analysis to identify metabolic profiles for obesity, adjusting for standard obesity indicators. After adjusting for covariates and multiple testing, five metabolites were associated with body mass index and seven were associated with waist circumference. Of them, three were associated with both. Majority of the obesity-related metabolites belongs to lipids, e.g., fatty amides, sphingolipids, prenol lipids, and steroid derivatives. Other identified metabolites are amino acids or peptides. Of the nine identified metabolites, five metabolites (oleoylethanolamide, mannosyl-diinositol-phosphorylceramide, pristanic acid, glutamate, and kynurenine) have been previously implicated in obesity or its related pathways. Future studies are warranted to replicate these findings in larger populations or other ethnic groups
UR  - https://dx.doi.org/10.1371/journal.pone.0159548
ER  -