TY  - BOOK
AU  - Ben-Dor, Itsik
AU  - Buchanan, Kyle
AU  - Gajanana, Deepakraj
AU  - Iantorno, Micaela
AU  - Okubagzi, Petros
AU  - Pichard, Augusto D
AU  - Rogers, Toby
AU  - Satler, Lowell F
AU  - Torguson, Rebecca
AU  - Waksman, Ron
TI  - Antiplatelet and anticoagulation regimen in patients with mechanical valve undergoing PCI - State-of-the-art review
SN  - 0167-5273
PY  - 2018///
KW  - *Anticoagulants
KW  - *Drug Therapy, Combination
KW  - *Heart Valve Prosthesis
KW  - *Hemorrhage
KW  - *Percutaneous Coronary Intervention/mt [Methods]
KW  - *Platelet Aggregation Inhibitors
KW  - *Purinergic P2Y Receptor Antagonists
KW  - Anticoagulants/ad [Administration & Dosage]
KW  - Anticoagulants/ae [Adverse Effects]
KW  - Drug Therapy, Combination/ae [Adverse Effects]
KW  - Drug Therapy, Combination/mt [Methods]
KW  - Heart Valve Prosthesis/cl [Classification]
KW  - Heart Valve Prosthesis/st [Standards]
KW  - Hemorrhage/ci [Chemically Induced]
KW  - Hemorrhage/pc [Prevention & Control]
KW  - Humans
KW  - Platelet Aggregation Inhibitors/ad [Administration & Dosage]
KW  - Platelet Aggregation Inhibitors/ae [Adverse Effects]
KW  - Purinergic P2Y Receptor Antagonists/ad [Administration & Dosage]
KW  - Purinergic P2Y Receptor Antagonists/ae [Adverse Effects]
KW  - Risk Adjustment
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - A common clinical dilemma regarding treatment of patients with a mechanical valve is the need for concomitant antiplatelet therapy for a variety of reasons, referred to as triple therapy. Triple therapy is when a patient is prescribed aspirin, a P2Y12 antagonist, and an oral anticoagulant. Based on the totality of the available evidence, best practice in 2017 for patients with mechanical valves undergoing percutaneous coronary intervention (PCI) is unclear. Furthermore, the optimal duration of dual antiplatelet therapy after PCI is evolving. With better valve designs that are less thrombogenic, the thromboembolic risks can be reduced at a lower international normalized ratio target, thus decreasing the bleeding risk. This review will offer an in-depth survey of current guidelines, current evidence, suggested approach for PCI in this cohort, and future studies regarding mechanical valve patients undergoing PCI; Copyright (c) 2017 Elsevier B.V. All rights reserved
UR  - https://dx.doi.org/10.1016/j.ijcard.2018.03.107
ER  -