TY  - BOOK
AU  - Burman, Kenneth D
AU  - Garcia, Carlos
AU  - Kulkarni, Kanchan
AU  - Plyku, Donika
AU  - Van Nostrand, Douglas
AU  - Wartofsky, Leonard
AU  - Wu, Di
TI  - The spectrum of 124I uptake in the lacrimal gland and nasolacrimal sac/duct on PET/CT imaging
SN  - 0143-3636
PY  - 2021///
KW  - *Iodine Radioisotopes/me [Metabolism]
KW  - *Lacrimal Apparatus/dg [Diagnostic Imaging]
KW  - *Lacrimal Apparatus/me [Metabolism]
KW  - *Nasolacrimal Duct/dg [Diagnostic Imaging]
KW  - *Nasolacrimal Duct/me [Metabolism]
KW  - *Positron Emission Tomography Computed Tomography
KW  - Adult
KW  - Biological Transport
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Medicine/Nuclear Medicine
KW  - Journal Article
N1  - Available online through MWHC library: 2003 - present
N2  - CONCLUSIONS: In patients with DTC, I activity in the NLDs is more frequently visualized, more intense, more prolonged, and more variable than in the lacrimal glands. The lack of clearance may suggest possible obstruction or stasis of an NLD; METHODS: I PET/CT in 31 DTC patients was performed at 2, 24, 48, 72, and 96 h after oral administration of 31.5 or 62.9 MBq (0.85 or 1.7 mCi) of I after either recombinant human thyroid-stimulating hormone injections or thyroid hormone withdrawal. All but two patients had a history of prior I therapy. Patterns of I uptake in the lacrimal glands and nasolacrimal sac/ducts (NLD) were assessed; RESULTS: A total of 173 individual I PET/CT scans (forming 35 sets of scans) were reviewed for 31 patients. Lacrimal glands were visualized bilaterally in only 4 patients. The focal mild uptake (grade 2), best seen on the 2-h images, was crescent-shaped and located in the lateral upper quadrant of the orbit. In contrast, the NLDs were identified in all patients (bilateral in 29 of 31 patients) with high focal uptake (grade 4) peaking on the 2- and 24-h timepoints; however, the overall pattern of uptake was variable. Of the 29 patients with prior I therapy, three patients had a relatively fixed and unchanging pattern of uptake on at least one side of the NLDs; This study characterizes the spectrum of physiologic I uptake of the lacrimal system in patients with a history of differentiated thyroid cancer (DTC) who underwent multi-timepoint I PET/CT imaging
UR  - https://dx.doi.org/10.1097/MNM.0000000000001330
ER  -