TY  - BOOK
AU  - Barac, Ana
AU  - Carter, Elizabeth A
AU  - Howard, Barbara V
AU  - Panza, Julio A
AU  - Shara, Nawar M
AU  - Umans, Jason G
AU  - Wang, Hong
TI  - Markers of inflammation, metabolic risk factors, and incident heart failure in American Indians: the Strong Heart Study
SN  - 1524-6175
PY  - 2012///
KW  - *C-Reactive Protein/me [Metabolism]
KW  - *Fibrinogen/me [Metabolism]
KW  - *Heart Failure
KW  - *Inflammation
KW  - Aged
KW  - Biological Markers
KW  - Diabetes Mellitus/ep [Epidemiology]
KW  - Female
KW  - Health Surveys
KW  - Heart Failure/ep [Epidemiology]
KW  - Heart Failure/et [Etiology]
KW  - Heart Failure/me [Metabolism]
KW  - Humans
KW  - Indians, North American
KW  - Inflammation/co [Complications]
KW  - Inflammation/me [Metabolism]
KW  - Male
KW  - Metabolic Syndrome X/ep [Epidemiology]
KW  - Middle Aged
KW  - Obesity/ep [Epidemiology]
KW  - Prevalence
KW  - Proportional Hazards Models
KW  - Risk Factors
KW  - United States/eh [Ethnology]
KW  - United States/ep [Epidemiology]
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: 2001 - present
N2  - Inflammation may play a role in increased risk of heart failure (HF) that is associated with obesity, metabolic syndrome (MS), and diabetes. This study investigated associations between inflammatory markers, MS, and incident HF in a population with a high prevalence of diabetes, obesity, and MS. The cohort consisted of 3098 American Indians without prevalent cardiovascular disease who had C-reactive protein (CRP) and fibrinogen measured at the Strong Heart Study phase II examination. Independent associations between inflammatory markers, MS, and HF were analyzed by Cox hazard models. During a mean follow-up of 11 years, 218 participants developed HF. After the adjustment for cardiovascular risk factors, fibrinogen, (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.15-1.59) but not CRP (HR, 1.25; 95% CI, 0.97-1.32) remained a significant HF predictor. In individuals without diabetes, concomitant presence of MS and elevated CRP or fibrinogen increased HF risk (for MS and CRP: HR, 2.02; 95% CI, 0.95-4.31; for CRP and fibrinogen: HR, 1.75; 95% CI, 0.83-3.72). In a population with a high prevalence of obesity, MS, and diabetes, elevated CRP and fibrinogen increased HF risk. These associations are attenuated by the adjustments for conventional risk factors suggesting that inflammation acts in concert with metabolic and clinical risk factors in increasing HF risk.  2011 Wiley Periodicals, Inc
UR  - http://dx.doi.org/10.1111/j.1751-7176.2011.00560.x
ER  -