Blessing in disguise; a case of Hereditary Persistence of Fetal Hemoglobin. 

 -  2018 
<br/><br/> Fetal Hemoglobin (HbF, alpha2gamma2) is produced from the eighth week of gestation, constitutes 60 - 80 % of total hemoglobin by birth, which is then replaced with adult Hemoglobin A1 (HbA1: alpha2beta2) by 6-12 months. Hereditary Persistence of Fetal Hemoglobin (HPFH) is a rare benign asymptomatic genetic disorder where the HbF persists, and incidentally discovered on screening for other hemoglobinopathies. In adults, the variation in HbF levels could also be associated with other disease states, including hemoglobinopathies, leukemias and bone marrow failure syndromes. Here we present a case of a young asymptomatic female with the incidental finding of HPFH who was misdiagnosed as the sickle cell disease. It is important to have awareness about HPFH and should be distinguished from other causes of elevated HbF. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>2000-9666 
<br/><br/><label>Standard No.: </label>10.1080/20009666.2018.1536241 [doi] 1536241 [pii] PMC6292363 [pmc] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>IN PROCESS -- NOT YET INDEXED
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Franklin Square Medical Center<br/>Medstar Union Memorial Hospital
<br/><br/><label>Index Terms--Occupation: </label><br/>Internal Medicine
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article