TY  - BOOK
AU  - Ali, Syed
AU  - Asch, Federico M
AU  - Ben-Dor, Itsik
AU  - Case, Brian
AU  - Forrestal, Brian
AU  - Garcia-Garcia, Hector M
AU  - Malla, Prerna
AU  - Medranda, Giorgio
AU  - Rogers, Toby
AU  - Satler, Lowell F
AU  - Sciandra, Kathryn A
AU  - Shea, Corey
AU  - Shults, Christian
AU  - Sutton, Joseph A
AU  - Waksman, Ron
AU  - Weissman, Gaby
AU  - Zhang, Cheng
TI  - Prosthetic valve endocarditis after transcatheter aortic valve replacement in low-risk patients
SN  - 1522-1946
PY  - 2022///
KW  - *Aortic Valve Stenosis
KW  - *Endocarditis
KW  - *Endocarditis, Bacterial
KW  - *Heart Valve Prosthesis
KW  - *Transcatheter Aortic Valve Replacement
KW  - Aortic Valve Stenosis/co [Complications]
KW  - Aortic Valve Stenosis/dg [Diagnostic Imaging]
KW  - Aortic Valve Stenosis/su [Surgery]
KW  - Aortic Valve/dg [Diagnostic Imaging]
KW  - Aortic Valve/su [Surgery]
KW  - Endocarditis, Bacterial/co [Complications]
KW  - Endocarditis, Bacterial/di [Diagnosis]
KW  - Endocarditis, Bacterial/ep [Epidemiology]
KW  - Endocarditis/et [Etiology]
KW  - Heart Valve Prosthesis/ae [Adverse Effects]
KW  - Humans
KW  - Risk Factors
KW  - Transcatheter Aortic Valve Replacement/ae [Adverse Effects]
KW  - Treatment Outcome
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Advanced Cardiac Catheterization Research Fellowship
KW  - Interventional Cardiology Fellowship
KW  - Journal Article
N2  - BACKGROUND: PVE remains a rare but devastating complication of aortic valve replacement. Data regarding PVE after TAVR in low-risk patients are lacking; CONCLUSIONS: PVE was infrequent following TAVR in low-risk patients but was associated with substantial morbidity and mortality. Embolic stroke complicated the majority of PVE cases, contributing to worse outcomes in these patients. Efforts must be undertaken to minimize PVE in TAVR. Copyright (c) 2021 Wiley Periodicals LLC; METHODS: We performed a detailed review of all patients in the low-risk TAVR trials who underwent TAVR from 2016 to 2020 and were adjudicated to have definitive PVE by the independent Clinical Events Committee; OBJECTIVES: We sought to report details of the incidence, organisms, clinical course, and outcomes of prosthetic valve endocarditis (PVE) after transcatheter aortic valve replacement (TAVR) in low-risk patients; RESULTS: We analyzed 396 low-risk patients who underwent TAVR (including 72 with bicuspid valves). PVE occurred in 11 patients at a median 379 days (210, 528) from TAVR. The incidence within the first 30 days was 0%; days 31-365, 1.5%; and after day 365, 2.8%. The most common organism identified was Streptococcus (n = 4/11). Early PVE (<= 365 days) occurred in five patients, of whom three demonstrated evidence of embolic stroke and two underwent surgical aortic valve re-intervention. Late PVE (> 365 days) occurred in six patients, of whom thee demonstrated evidence of embolic stroke and only one underwent surgical aortic valve re-intervention. Of the six patients with evidence of embolic stroke, two died, two were discharged to rehabilitation, and two were discharged home with home care
UR  - https://dx.doi.org/10.1002/ccd.29943
ER  -