TY  - BOOK
AU  - Boyajian, Michael J
TI  - Age at initial consultation for craniosynostosis: comparison across different patient characteristics
SN  - 1049-2275
PY  - 2013///
KW  - *Craniosynostoses/su [Surgery]
KW  - *Reconstructive Surgical Procedures/mt [Methods]
KW  - Age Factors
KW  - Familial Hypophosphatemic Rickets/su [Surgery]
KW  - Female
KW  - Humans
KW  - Infant
KW  - Male
KW  - Phenotype
KW  - MedStar Washington Hospital Center
KW  - Surgery/Plastic Surgery
KW  - Comparative Study
KW  - Journal Article
N1  - Available online from MWHC library: 2001 - present, Available in print through MWHC library:1999-2007
N2  - BACKGROUND: The severity and dysmorphology that results from the premature fusion of one or more cranial sutures is not uniform. Less striking phenotypes may be more easily missed on routine screening, possibly leading to delayed diagnosis and treatment. The purpose of this study was to compare the age at initial presentation for the different forms of craniosynostosis; CONCLUSIONS: Patients with multisutural involvement or X-linked hypophosphatemic rickets had a significant delay in presentation for craniosynostosis. The latter group of patients may especially benefit from routine surveillance for craniosynostosis given their advanced age at diagnosis; METHODS: The authors reviewed the records of all patients who underwent open craniofacial repair of craniosynostosis at a single institution from 1996 to 2009. Relationships between type of suture fusion and age at initial consultation were compared; RESULTS: Two hundred eleven patients (136 males, 75 females) were identified. Indications included sagittal (n = 96), metopic (n = 39), unicoronal (n = 33), bicoronal (n = 24), multisutural (n = 15), bilambdoidal (n = 3), and unilambdoidal (n = 1) synostoses. Seventeen patients (8.1%) had a craniosynostosis syndrome and 5 (2.4%) had a syndrome or disorder not typically associated with craniosynostosis [X-linked hypophosphatemic rickets (n = 3), achondroplasia (n = 1), and Beckwith Wiedemann (n = 1)]. Median age at initial consultation was 4.1 months; there was no gender difference. Patients with X-linked hypophosphatemic rickets presented at a significantly older age than nonsyndromic patients or those with a known craniosynostosis syndrome. Those with multisutural synostosis presented at a significantly older age than patients with sagittal or bicoronal synostosis
UR  - http://dx.doi.org/10.1097/SCS.0b013e318270fb83
ER  -