TY  - BOOK
AU  - Asch, Federico M
AU  - Bruce, Adrienne
AU  - Krepp, Joseph M
TI  - Bicuspid and unicuspid aortic valves: Different phenotypes of the same disease? Insight from the GenTAC Registry
SN  - 1747-079X
PY  - 2017///
KW  - *Aortic Valve/ab [Abnormalities]
KW  - *Heart Valve Diseases/ge [Genetics]
KW  - *Registries
KW  - Adolescent
KW  - Adult
KW  - Aorta/dg [Diagnostic Imaging]
KW  - Aortic Valve/dg [Diagnostic Imaging]
KW  - Child
KW  - Child, Preschool
KW  - Diagnosis, Differential
KW  - Echocardiography
KW  - Female
KW  - Heart Valve Diseases/cn [Congenital]
KW  - Heart Valve Diseases/di [Diagnosis]
KW  - Humans
KW  - Infant
KW  - Male
KW  - Middle Aged
KW  - Phenotype
KW  - Retrospective Studies
KW  - Young Adult
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - BACKGROUND: Unicuspid aortic valve (UAV) is a rare disorder, often difficult to distinguish from bicuspid aortic valve (BAV). BAV and UAV share valve pathology such as the presence of a raphe, leaflet fusion, aortic stenosis, aortic regurgitation, and/or ascending aortic dilatation, but a comprehensive echocardiographic comparison of patients with UAV and BAV has not been previously performed; CONCLUSIONS: The similar baseline characteristics with more accelerated aortic valve degeneration and stenosis suggest that UAV represents an extreme in the spectrum of BAV syndromes. Therefore, it is reasonable to consider application of recommendations for the management of patients with BAV to those with the rarer UAV. Copyright (c) 2017 Wiley Periodicals, Inc; METHODS: We investigated UAV and BAV patients at an early stage of disease included in GenTAC, a national registry of genetically related aortic aneurysms and associated cardiac conditions. Clinical and echocardiographic data from the GenTAC Registry were compared between 17 patients with UAV and 17 matched-controls with BAV; RESULTS: Baseline characteristics including demographics, clinical findings including family history of BAV and aortic aneurysm/coarctation, and echocardiographic variables were similar between BAV and UAV patients; aortic stenosis was more common and more severe in patients with UAV. This was evidenced by higher mean and peak gradient, smaller aortic valve area, and more advanced valvular degeneration (all P < .05). There were no significant differences in aortic dimensions, with a similar pattern of enlargement of the ascending aorta
UR  - https://dx.doi.org/10.1111/chd.12520
ER  -