TY  - BOOK
AU  - Pothoulakis, Ioannis
TI  - Incidence and risk factors of oral feeding intolerance in acute pancreatitis: results from an international, multicenter, prospective cohort study
SN  - 2050-6406
PY  - 2021///
KW  - *Eating
KW  - *Food Intolerance/et [Etiology]
KW  - *Pancreatitis/co [Complications]
KW  - Abdominal Pain/et [Etiology]
KW  - Adult
KW  - Age Factors
KW  - Alcohol Drinking/ae [Adverse Effects]
KW  - Blood Urea Nitrogen
KW  - Female
KW  - Hematocrit
KW  - Humans
KW  - Length of Stay
KW  - Male
KW  - Middle Aged
KW  - Prospective Studies
KW  - Regression Analysis
KW  - Risk Factors
KW  - ROC Curve
KW  - Sex Factors
KW  - Smoking/ae [Adverse Effects]
KW  - Vomiting/et [Etiology]
KW  - MedStar Georgetown University Hospital Residents
KW  - Journal Article
N2  - BACKGROUND: Inability to advance to an oral diet, or oral feeding intolerance, is a common complication in patients with acute pancreatitis associated with worse clinical outcomes. The factors related to oral feeding intolerance are not well studied; CONCLUSION: Oral feeding intolerance occurs in 13% of acute pancreatitis patients and is independently associated with systemic inflammatory response syndrome at 48 hours and a non-biliary etiology; METHODS: Patients were prospectively enrolled in the Acute Pancreatitis Patient Registry to Examine Novel Therapies in Clinical Experience (APPRENTICE), an international acute pancreatitis registry, between 2015 and 2018. Oral feeding intolerance was defined as worsening abdominal pain and/or vomiting after resumption of oral diet. The timing of the initial feeding attempt was stratified based on the day of hospitalization. Multivariable logistic regression was performed to assess for independent risk factors/predictors of oral feeding intolerance; OBJECTIVE: We aimed to determine the incidence and risk factors of oral feeding intolerance in acute pancreatitis; RESULTS: Of 1233 acute pancreatitis patients included in the study, 160 (13%) experienced oral feeding intolerance. The incidence of oral feeding intolerance was similar irrespective of the timing of the initial feeding attempt relative to hospital admission day (P = 0.41). Patients with oral feeding intolerance were more likely to be younger (45 vs. 50 years of age), men (61% vs. 49%) and active alcohol users (44% vs. 36%). They also had higher blood urea nitrogen (20 vs. 15 mg/dL; P<0.001) and hematocrit levels (41.7% vs. 40.5%; P = 0.017) on admission; were more likely to have a non-biliary acute pancreatitis etiology (69% vs. 51%), systemic inflammatory response syndrome of 2 or greater on admission (49% vs. 35%) and at 48 hours (50% vs. 26%;), develop pancreatic necrosis (29% vs. 13%), moderate to severe acute pancreatitis (41% vs. 24%) and have a longer hospital stay (10 vs. 6 days; all P<0.04). The adjusted analysis showed that systemic inflammatory response syndrome of 2 or greater at 48 hours (odds ratio 3.10; 95% confidence interval 1.83-5.25) and a non-biliary acute pancreatitis etiology (odds ratio 1.65; 95% confidence interval 1.01-2.69) were independent risk factors for oral feeding intolerance
UR  - https://dx.doi.org/10.1177/2050640620957243
ER  -