TY  - BOOK
AU  - Howard, Barbara V
TI  - A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians
SN  - 0012-1797
KW  - *Diabetes Mellitus, Type 2/ge [Genetics]
KW  - *Genetic Variation
KW  - *Indians, North American/ge [Genetics]
KW  - *Insulin Resistance/ge [Genetics]
KW  - *Receptors, Nicotinic/ge [Genetics]
KW  - Adult
KW  - Aged
KW  - Blood Glucose/an [Analysis]
KW  - Diabetes Mellitus, Type 2/ep [Epidemiology]
KW  - Female
KW  - Genetic Association Studies/sn [Statistics & Numerical Data]
KW  - Genetic Predisposition to Disease
KW  - Humans
KW  - Insulin/bl [Blood]
KW  - Male
KW  - Middle Aged
KW  - Pedigree
KW  - Polymorphism, Single Nucleotide
KW  - Smoking/ep [Epidemiology]
KW  - Smoking/ge [Genetics]
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006
N2  - Cigarette smoking is a risk factor for type 2 diabetes. Genetic variants in the nicotinic acetylcholine receptor (nAChR) genes have been associated with smoking phenotypes and are likely to influence diabetes. Although each single variant may have only a minor effect, the joint contribution of multiple single nucleotide polymorphisms (SNPs) to the occurrence of disease may be larger. In this study, we conducted a gene-family analysis to investigate the joint impact of 61 tag SNPs in 7 nAChRs genes on insulin resistance and type 2 diabetes in 3,665 American Indians recruited by the Strong Heart Family Study. Results show that although multiple SNPs showed marginal individual association with insulin resistance and type 2 diabetes, only a few can pass adjustment for multiple testing. However, a gene-family analysis considering the joint impact of all 61 SNPs reveals significant association of the nAChR gene family with both insulin resistance and type 2 diabetes (both P < 0.0001), suggesting that genetic variants in the nAChR genes jointly contribute to insulin resistance and type 2 diabetes among American Indians. The effects of these genetic variants on insulin resistance and diabetes are independent of cigarette smoking per se
UR  - http://dx.doi.org/10.2337/db11-1393
ER  -