A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women. 

<br/><br/>Available online from MWHC library: 1995 - present (after 3 months), Available in print through MWHC library: 1999 - 2006 
<br/><br/> Telomere length (TL) has been implicated in the pathogenesis of age-related disorders. However, there are no prospective studies directly investigating the role of TL and relevant genes in diabetes development. In the multiethnic Women's Health Initiative, we identified 1,675 incident diabetes case participants in 6 years of follow-up and 2,382 control participants matched by age, ethnicity, clinical center, time of blood draw, and follow-up duration. Leukocyte TL at baseline was measured using quantitative PCR, and Mendelian randomization analysis was conducted to test whether TL is causally associated with diabetes risk. After adjustment for matching and known diabetes risk factors, odds ratios per 1-kilobase increment were 1.00 (95% CI 0.90-1.11) in whites, 0.95 (0.85-1.06) in blacks, 0.96 (0.79-1.17) in Hispanics, and 0.88 (0.70-1.10) in Asians. Of the 80 single nucleotide polymorphisms (SNPs) in nine genes involved in telomere regulation, 14 SNPs were predictive of TL, but none were significantly associated with diabetes risk. Using ethnicity-specific SNPs as randomization instruments, we observed no statistically significant association between TL and diabetes risk (P = 0.52). Although leukocyte TL was weakly associated with diabetes risk, this association was not independent of known risk factors. These prospective findings indicate limited clinical utility of TL in diabetes risk stratification among postmenopausal women. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0012-1797 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Diabetes Mellitus, Type 2/ge [Genetics]<br/>*Leukocytes/me [Metabolism]<br/>*Telomere Shortening<br/>Aged<br/>Cohort Studies<br/>Diabetes Mellitus, Type 2/bl [Blood]<br/>Diabetes Mellitus, Type 2/eh [Ethnology]<br/>Diabetes Mellitus, Type 2/ep [Epidemiology]<br/>Female<br/>Follow-Up Studies<br/>Genetic Association Studies<br/>Humans<br/>Mendelian Randomization Analysis<br/>Middle Aged<br/>Polymerase Chain Reaction<br/>Polymorphism, Single Nucleotide<br/>Postmenopause<br/>Prospective Studies<br/>Risk Factors<br/>Telomere-Binding Proteins/ge [Genetics]<br/>Telomere-Binding Proteins/me [Metabolism]<br/>United States/ep [Epidemiology]
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Health Research Institute
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Research Support, N.I.H., Extramural