Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage.[Erratum appears in Stroke. 2012 Nov;43(11):e171] 

<br/><br/>Available online from MWHC library: 1970 - present, Available in print through MWHC library: 1999 - 2006 
<br/><br/> BACKGROUND AND PURPOSE: Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH diagnosis of HTN.  CONCLUSIONS: Increasing numbers of high blood pressure-related alleles are associated with increased risk of deep ICH as well as with clinically identified HTN.  METHODS: We conducted a prospective multicenter case-control study in 2272 subjects of European ancestry (1025 cases and 1247 control subjects). Thirty-nine SNPs reported to be associated with blood pressure levels were identified from the National Human Genome Research Institute genomewide association study catalog. Single-SNP association analyses were performed for the outcomes ICH and pre-ICH HTN. Subsequently, weighted and unweighted genetic risk scores were constructed using these SNPs and entered as the independent variable in logistic regression models with ICH and pre-ICH HTN as the dependent variables.  RESULTS: No single SNP was associated with either ICH or pre-ICH HTN. The blood pressure-based unweighted genetic risk score was associated with risk of ICH (OR, 1.11; 95% CI, 1.02-1.21; P=0.01) and the subset of ICH in deep regions (OR, 1.18; 95% CI, 1.07-1.30; P=0.001), but not with the subset of lobar ICH. The score was associated with a history of HTN among control subjects (OR, 1.17; 95% CI, 1.04-1.31; P=0.009) and ICH cases (OR, 1.15; 95% CI, 1.01-1.31; P=0.04). Similar results were obtained when using a weighted score. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0039-2499 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Genetic Predisposition to Disease/ge [Genetics]<br/>*Hypertension/ge [Genetics]<br/>*Intracranial Hemorrhage, Hypertensive/ge [Genetics]<br/>Aged<br/>Alleles<br/>Case-Control Studies<br/>Female<br/>Genotype<br/>Humans<br/>Hypertension/co [Complications]<br/>Male<br/>Polymorphism, Single Nucleotide<br/>Risk Factors
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Heart & Vascular Institute
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Multicenter Study<br/>Research Support, N.I.H., Extramural<br/>Research Support, Non-U.S. Gov't