TY  - BOOK
AU  - Reddy, Uma M
TI  - The association of cord serum cytokines with neurodevelopmental outcomes
SN  - 0735-1631
PY  - 2015///
KW  - *Cerebral Palsy/bl [Blood]
KW  - *Cytokines/bl [Blood]
KW  - *Developmental Disabilities/bl [Blood]
KW  - *Fetal Blood/me [Metabolism]
KW  - *Interleukin-1beta/bl [Blood]
KW  - *Interleukin-8/bl [Blood]
KW  - *Premature Birth/bl [Blood]
KW  - *Tumor Necrosis Factor-alpha/bl [Blood]
KW  - Adult
KW  - Case-Control Studies
KW  - Cerebral Palsy/di [Diagnosis]
KW  - Cerebral Palsy/pc [Prevention & Control]
KW  - Child Development
KW  - Child, Preschool
KW  - Developmental Disabilities/di [Diagnosis]
KW  - Female
KW  - Humans
KW  - Infant
KW  - Infant, Newborn
KW  - Infant, Premature
KW  - Logistic Models
KW  - Magnesium Sulfate/tu [Therapeutic Use]
KW  - Pregnancy
KW  - Prognosis
KW  - Tocolytic Agents/tu [Therapeutic Use]
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology, Maternal-Fetal Medicine
KW  - Journal Article
KW  - Randomized Controlled Trial
KW  - Research Support, N.I.H., Extramural
N2  - CONCLUSION: Cord serum IL-8, IL-1beta, and TNF-alpha levels in preterm infants are not associated with subsequent CP or NDD.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA; OBJECTIVE: To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD); RESULTS: Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1beta were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1beta, and TNF-alpha) were not elevated with CP or low PDI; STUDY DESIGN: Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI)<70. Controls, defined as surviving children without CP and with Bayley PDI and MDI>85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. Elevated cytokine levels were defined as>75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences
UR  - http://dx.doi.org/10.1055/s-0034-1376185
ER  -