TY  - BOOK
AU  - Graham, Autumn
AU  - Kappler, Shane
TI  - Thrombotic microangiopathies (TTP, HUS, HELLP). [Review]
SN  - 0733-8627
KW  - *Thrombotic Microangiopathies/di [Diagnosis]
KW  - Adult
KW  - Child
KW  - Female
KW  - HELLP Syndrome/di [Diagnosis]
KW  - HELLP Syndrome/th [Therapy]
KW  - Hemolytic-Uremic Syndrome/di [Diagnosis]
KW  - Hemolytic-Uremic Syndrome/th [Therapy]
KW  - Humans
KW  - Immunosuppressive Agents/tu [Therapeutic Use]
KW  - Pregnancy
KW  - Purpura, Thrombotic Thrombocytopenic/di [Diagnosis]
KW  - Purpura, Thrombotic Thrombocytopenic/th [Therapy]
KW  - Thrombocytopenia/et [Etiology]
KW  - Thrombotic Microangiopathies/et [Etiology]
KW  - Thrombotic Microangiopathies/th [Therapy]
KW  - MedStar Washington Hospital Center
KW  - Emergency Medicine
KW  - Journal Article
KW  - Review
N1  - Available online from MWHC library: 1996 - present
N2  - Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. One group of disorders leading to thrombocytopenia is the thrombotic microangiopathies, hallmarked by platelet destruction. These thrombotic microangiopathies include thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzyme levels, low platelet count (HELLP), which should be distinguished from similar disease processes such as immune thrombocytopenia (ITP), disseminated intravascular coagulation (DIC) and heparin induced thrombocytopenia (HIT). In this article, clinical presentations, pathophysiology, diagnostic workup, management plans, complications, and dispositions are addressed for this complex group of platelet disorders. Copyright  2014 Elsevier Inc. All rights reserved
UR  - http://dx.doi.org/10.1016/j.emc.2014.04.008
ER  -