TY  - BOOK
AU  - Najjar, Samer S
AU  - Shetty, Veena
TI  - Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging)
SN  - 0735-1097
PY  - 2013///
KW  - *Aging/ph [Physiology]
KW  - *Exercise Test/ae [Adverse Effects]
KW  - *Tachycardia, Ventricular/ep [Epidemiology]
KW  - *Tachycardia, Ventricular/et [Etiology]
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Baltimore
KW  - Confidence Intervals
KW  - Electrocardiography/mt [Methods]
KW  - Female
KW  - Geriatric Assessment/mt [Methods]
KW  - Human Experimentation
KW  - Humans
KW  - Kaplan-Meier Estimate
KW  - Longitudinal Studies
KW  - Male
KW  - Middle Aged
KW  - Multivariate Analysis
KW  - Prevalence
KW  - Proportional Hazards Models
KW  - Prospective Studies
KW  - Reference Values
KW  - Severity of Illness Index
KW  - Sex Factors
KW  - Survival Rate
KW  - Tachycardia, Ventricular/di [Diagnosis]
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Comparative Study
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - BACKGROUND: Prior studies have reported variable risk associated with exercise-induced ventricular arrhythmia; CONCLUSIONS: Exercise-induced NSVT occurred in nearly 4% of this asymptomatic adult cohort. This finding increased with age and was more common in men. After adjustment for clinical variables, exercise-induced NSVT did not independently increase the risk of total mortality. Copyright  2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved; METHODS: Subjects in the BLSA (Baltimore Longitudinal Study of Aging) free of known cardiovascular disease who completed at least 1 symptom-limited exercise treadmill test between 1977 and 2001 were included. NSVT episodes were characterized by QRS morphology, duration, and rate. Subjects underwent follow-up clinical evaluation every 2 years; OBJECTIVES: This study sought to determine the clinical predictors and prognostic significance of exercise-induced nonsustained ventricular tachycardia (NSVT) in a large population of asymptomatic volunteers; RESULTS: The 2,099 subjects (mean age: 52 years; 52.2% male) underwent a mean of 2.7 exercise tests, in which 79 (3.7%)developed NSVT with exercise on at least 1 test. The median duration of NSVT was 3 beats (<=5 beats in 84%), and the median rate was 175 beats/min. Subjects with (vs. without) NSVT were older (67 +/- 12 years vs. 51+/-17 years, p< 0.0001) and more likely to be male (80% vs. 51%, p< 0.0001) and to have baseline electrocardiographic abnormalities (50% vs. 17%, p< 0.0001) or ischemic ST-segment 131223s with exercise (20% vs. 10%, p= 0.004). Over a mean follow-up of 13.5 +/- 7.7 years, 518 deaths (24.6%) occurred. After multivariable adjustment for age, sex, and coronary risk factors, exercise-induced NSVT was not significantly associated with total mortality (hazard ratio: 1.30; 95% confidence interval: 0.89 to 1.90; p= 0.17)
UR  - http://dx.doi.org/10.1016/j.jacc.2013.05.026
ER  -