TY  - BOOK
AU  - Hofmeyer, Mark
TI  - Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives
SN  - 0735-1097
PY  - 2023///
KW  - *Cardiomyopathy, Dilated
KW  - Adult
KW  - Black People
KW  - Cardiomyopathy, Dilated/di [Diagnosis]
KW  - Cardiomyopathy, Dilated/ge [Genetics]
KW  - Echocardiography
KW  - Ethnicity
KW  - Female
KW  - Hispanic or Latino
KW  - Humans
KW  - Hypertrophy, Left Ventricular
KW  - Male
KW  - Middle Aged
KW  - Curated
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - BACKGROUND: Cardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD); CONCLUSIONS: Cardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs. Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved; METHODS: Adult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics results; OBJECTIVES: This study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients; RESULTS: A total of 1,365 FDRs were included, with a mean age of 44.8 +/- 16.9 years, 27.5% non-Hispanic Black, 9.8% Hispanic, and 61.7% women. Among screened FDRs, 14.1% had new diagnoses of DCM (2.1%), LVSD (3.6%), or LVE (8.4%). The percentage of FDRs with new diagnoses was higher for those aged 45 to 64 years than 18 to 44 years. The age-adjusted percentage of any finding was higher among FDRs with hypertension and obesity but did not differ statistically by race and ethnicity (16.2% for Hispanic, 15.2% for non-Hispanic Black, and 13.1% for non-Hispanic White) or sex (14.6% for women and 12.8% for men). FDRs whose probands carried clinically reportable variants were more likely to be identified with DCM
UR  - https://dx.doi.org/10.1016/j.jacc.2023.03.419
ER  -