TY  - BOOK
AU  - Jaskille, Amin D
AU  - Jeng, James C
AU  - Jordan, Marion H
AU  - Kath, Melissa A
AU  - Matt, Sarah E
AU  - Pavlovich, Anna R
AU  - Shoham, Shmuel
AU  - Shupp, Jeffrey W
TI  - Early serum (1->3)--D-glucan levels in patients with burn injury
SN  - 0933-7407
PY  - 2012///
KW  - *beta-Glucans/bl [Blood]
KW  - *Burns/co [Complications]
KW  - *Candidemia/bl [Blood]
KW  - Burns/bl [Blood]
KW  - Candida/ip [Isolation & Purification]
KW  - Candida/ph [Physiology]
KW  - Candidemia/di [Diagnosis]
KW  - Candidemia/et [Etiology]
KW  - Candidemia/mi [Microbiology]
KW  - Female
KW  - Humans
KW  - Prospective Studies
KW  - MedStar Washington Hospital Center
KW  - Medicine/Infectious Diseases
KW  - Surgery/Burn Services
KW  - Journal Article
N2  - Serum (1->3)--D-glucan (BG) is increasingly used as diagnostic marker for invasive fungal infections. Exposure to gauze may lead to false-positive BG assays. The role of BG is unclear in thermally injured patients who frequently require extensive gauze coverage; therefore, we prospectively evaluated BG levels in burn-injured patients. Serum BG levels were measured in 18 burn patients immediately before application of the first dressing and 12 h after. Patients were stratified by extent of total body surface area (TBSA) requiring gauze coverage: <20%, 20-39%, 40-60% and >60%. BG levels were obtained from patients with non-burn trauma as controls. BG results were positive (>80 pg ml-1) in 9/18 (50%) patients at baseline and in 8/18 (44%) 12 h after application of the first dressing. BG levels were positive in 1/5 (20%) of patients with <20% TBSA requiring gauze and in 10/13 (77%) with >= 20% (P < 0.05). None of the control patients had positive BG at any time point and none of the patients had candidemia at baseline. Mean serum BG levels decreased (19.44 pg ml-1) after gauze placement. False-positive serum BG elevations are common in this patient population. Positivity correlates with extent of TBSA injured, but is not impacted by the gauze itself.  2011 Blackwell Verlag GmbH
UR  - http://dx.doi.org/10.1111/j.1439-0507.2011.02068.x
ER  -