TY  - BOOK
AU  - Beyene, Solomon
AU  - Calderon, Andrea Teira
AU  - Garcia-Garcia, Hector M
AU  - Garg, Mohil
AU  - Gkargkoulas, Fotis
AU  - Waksman, Ron
TI  - Comparison of endothelial shear stress between ultrathin strut Bioresorbable Polymer Drug Eluting Stent vs Durable Polymer Drug Eluting Stent post-stent implantation: An optical coherence tomography substudy from BIOFLOW II
SN  - 1878-0938
PY  - 2023///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Internal Medicine Residency
KW  - Journal Article
N1  - Available in print through MWHC library: 2002 - present
N2  - BACKGROUND: Recent clinical data indicate a different performance of biodegradable polymer (BP)-drug eluting stent (DES) compared to durable polymer (DP)-DES. Whether this can be explained by a beneficial impact of BP-DES stent design on the local hemodynamic forces distribution remains unclear; CONCLUSION: In this OCT sub-study of the BIOFLOW II trial, the NIT was statistically different between groups of patients treated with BP-DES and DP-DES. In addition, regions of low ESS were associated with increased NIT in all studied devices. Copyright © 2023 Elsevier Inc. All rights reserved; METHODS AND RESULTS: We retrospectively identified patients from the BIOFLOW II trial that had undergone OCT imaging. OCT data were utilized to reconstruct the surface of the stented segment at baseline and 9 months follow-up, simulate blood flow, and measure ESS and NIT in the stented segment. The patients were divided into 3 groups depending on whether DP-DES (N = 8, n = 56,160 sectors), BP-DES with a stent diameter of >3 mm (strut thickness of 80 mum, N = 6, n = 36,504 sectors), or BP-DES with a stent diameter of <=3 mm (strut thickness of 60 mum, N = 8, n = 50,040 sectors) were used for treatment. The ESS, and NIT distribution and the association of these two variables were estimated and compared among the 3 groups; OBJECTIVES: To compare endothelial shear stress (ESS) distribution after implantation of ultrathin (us) BP-DES and DP-DES and examine the association between ESS and neointimal thickness (NIT) distribution in the two devices at 9 months follow up; RESULTS: In the DP-DES group mean NIT was 0.18 +/- 0.17 mm and ESS 1.68 +/- 1.66 Pa; for the BP-DES <=3 mm group the NIT was 0.17 +/- 0.11 mm and ESS 1.49 +/- 1.24 Pa and for the BP-DES >3 mm group 0.20 +/- 0.23 mm and 1.42 +/- 1.24 Pa respectively (p < 0.001 for both NIT and ESS comparisons across groups). A negative correlation between NIT and baseline ESS was found, the correlation coefficient for all the stented segments was -0.33, p < 0.001
UR  - https://dx.doi.org/10.1016/j.carrev.2023.11.014
ER  -