TY  - BOOK
AU  - Baffour, Richard
AU  - Chan, Rosanna
AU  - Hellinga, David
AU  - Pakala, Rajbabu
AU  - Seabron, Rufus
AU  - Waksman, Ron
TI  - In vivo comparison of a polymer-free Biolimus A9-eluting stent with a biodegradable polymer-based Biolimus A9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries
SN  - 1522-1946
PY  - 2012///
KW  - *Absorbable Implants
KW  - *Angioplasty, Balloon/is [Instrumentation]
KW  - *Atherosclerosis/th [Therapy]
KW  - *Cardiovascular Agents/ad [Administration & Dosage]
KW  - *Drug-Eluting Stents
KW  - *Hypercholesterolemia/co [Complications]
KW  - *Iliac Artery/pa [Pathology]
KW  - *Metals
KW  - *Polymers
KW  - *Sirolimus/aa [Analogs & Derivatives]
KW  - *Stents
KW  - Animals
KW  - Atherosclerosis/et [Etiology]
KW  - Atherosclerosis/me [Metabolism]
KW  - Atherosclerosis/pa [Pathology]
KW  - Constriction, Pathologic
KW  - Disease Models, Animal
KW  - Fibrin/me [Metabolism]
KW  - Hyperplasia
KW  - Iliac Artery/me [Metabolism]
KW  - Iliac Artery/re [Radiation Effects]
KW  - Inflammation/pa [Pathology]
KW  - Male
KW  - Neointima
KW  - Plaque, Atherosclerotic
KW  - Prosthesis Design
KW  - Rabbits
KW  - Sirolimus/ad [Administration & Dosage]
KW  - Time Factors
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Comparative Study
KW  - Journal Article
N1  - Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006
N2  - CONCLUSION: This study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. Copyright  2011 Wiley Periodicals, Inc; METHODS: Rabbits were fed with 1% cholesterol diet (n = 14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After 4 weeks, BF (n = 8), BMF (n = 8), and BMS (n = 8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry; OBJECTIVES: To evaluate the effect of a polymer-free Biolimus A9-eluting stent [BioFreedom (BF)], compared with that of a biodegradable polymer-based Biolimus A9-eluting stent [BioMatrix Flex (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries; RESULTS: The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm(2) +/- 0.14 vs. 1.29 mm(2) +/- 0.23, P <0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (P <0.03 and <0.04) and giant cell number was significantly higher with both BMF and BF stents (P < 0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (P < 0.05 for both)
UR  - http://dx.doi.org/10.1002/ccd.2340
ER  -