TY  - BOOK
AU  - Waksman, Ron
TI  - Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the PREDICT trial
PY  - 2012///
KW  - *Coronary Artery Disease/di [Diagnosis]
KW  - *Genetic Testing
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Angioplasty, Balloon, Coronary
KW  - Coronary Angiography
KW  - Coronary Artery Bypass
KW  - Coronary Artery Disease/co [Complications]
KW  - Coronary Artery Disease/ge [Genetics]
KW  - Coronary Artery Disease/mo [Mortality]
KW  - Coronary Artery Disease/ra [Radiography]
KW  - Coronary Artery Disease/th [Therapy]
KW  - Female
KW  - Gene Expression Regulation
KW  - Genetic Predisposition to Disease
KW  - Humans
KW  - Ischemic Attack, Transient/et [Etiology]
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Myocardial Infarction/et [Etiology]
KW  - Odds Ratio
KW  - Phenotype
KW  - Predictive Value of Tests
KW  - Prognosis
KW  - Prospective Studies
KW  - Reproducibility of Results
KW  - Risk Assessment
KW  - Risk Factors
KW  - Stroke/et [Etiology]
KW  - Time Factors
KW  - United States
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
KW  - Multicenter Study
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N2  - The majority of first-time angiography patients are without obstructive coronary artery disease (CAD). A blood gene expression score (GES) for obstructive CAD likelihood was validated in the PREDICT study, but its relation to major adverse cardiovascular events (MACE) and revascularization was not assessed. Patients (N = 1,160) were followed up for MACE and revascularization 1 year post-index angiography and GES, with 1,116 completing follow-up. The 30-day event rate was 23% and a further 2.2% at 12 months. The GES was associated with MACE/revascularizations (p < 0.001) and added to clinical risk scores. Patients with GES >15 trended towards increased >30 days MACE/revascularization likelihood (odds ratio = 2.59, 95% confidence interval = 0.89-9.14, p = 0.082). MACE incidence overall was 1.5% (17 of 1,116) and 3 of 17 patients had GES <= 15. For the total low GES group (N = 396), negative predictive value was 90% for MACE/revascularization and >99% for MACE alone, identifying a group of patients without obstructive CAD and highly unlikely to suffer MACE within 12 months
UR  - http://dx.doi.org/10.1007/s12265-012-9353-z
ER  -