TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
AU  - Wang, Hong
TI  - Lipoprotein subfractions and dietary intake of n-3 fatty acid: the Genetics of Coronary Artery Disease in Alaska Natives study
SN  - 0002-9165
PY  - 2012///
KW  - *Cardiovascular Diseases/pc [Prevention & Control]
KW  - *Diet/eh [Ethnology]
KW  - *Dietary Fats/ad [Administration & Dosage]
KW  - *Energy Intake/eh [Ethnology]
KW  - *Fatty Acids, Omega-3/pd [Pharmacology]
KW  - *Inuits
KW  - *Lipoproteins/bl [Blood]
KW  - Adult
KW  - Alaska
KW  - Cardiovascular Diseases/eh [Ethnology]
KW  - Coronary Artery Disease
KW  - Female
KW  - Humans
KW  - Hyperlipidemias/eh [Ethnology]
KW  - Lipoproteins, HDL/bl [Blood]
KW  - Lipoproteins, LDL/bl [Blood]
KW  - Lipoproteins, VLDL/bl [Blood]
KW  - Magnetic Resonance Spectroscopy
KW  - Male
KW  - Middle Aged
KW  - Questionnaires
KW  - Risk Factors
KW  - Sex Factors
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: Sept 1992 - present, Available in print through MWHC library: 1999 - 2006
N2  - BACKGROUND: Few studies have compared lipoprotein composition with dietary intake; CONCLUSIONS: Dietary n-3 fatty acids, independent of the reciprocal changes in carbohydrate and sugar intakes, are associated with an overall favorable lipoprotein profile in terms of cardiovascular risk. Because there are no relations with total LDL particles, the benefit may be related to cardiovascular processes other than atherosclerosis; DESIGN: A population-based sample (n = 1214) from the Norton Sound Region of Alaska underwent a physical examination and blood sampling. Analyses were from 977 individuals who did not have diabetes or use lipid-lowering medications and had complete dietary information (food-frequency questionnaire) and a lipoprotein subfraction profile (nuclear magnetic resonance spectroscopy); OBJECTIVE: The lipoprotein subfraction profile was evaluated in relation to diet in Alaska Eskimos at high cardiovascular risk but with a low frequency of hyperlipidemia and high intake of n-3 (omega-3) fatty acids; RESULTS: After adjustment for age, BMI, total energy intake, and percentage of energy from fat, the intake of n-3 fatty acids was significantly associated with fewer large VLDLs (P = 0.022 in women, P = 0.064 in men), a smaller VLDL size (P = 0.018 and P = 0.036), more large HDLs (P = 0.179 and P = 0.021), and a larger HDL size (P = 0.004 and P = 0.001). After adjustment for carbohydrate and sugar intakes, large VLDLs (P = 0.042 and 0.018) and VLDL size (P = 0.011 and 0.025) remained negatively associated with n-3 fatty acid intake in women and men, and large HDLs (P = 0.067 and 0.005) and HDL size (P = 0.001 in both) remained positively associated with n-3 fatty acid intake in women and men. In addition, large LDLs (P = 0.040 and P = 0.025) were positively associated in both sexes, and LDL size (P = 0.006) showed a positive association in women. There were no significant relations with total LDL particles in either model
UR  - http://dx.doi.org/10.3945/ajcn.111.023887
ER  -