TY  - BOOK
AU  - Waksman, Ron
TI  - Bioresorbable drug-eluting magnesium-alloy scaffold: design and feasibility in a porcine coronary model
SN  - 1774-024X
PY  - 2013///
KW  - *Absorbable Implants
KW  - *Alloys/ch [Chemistry]
KW  - *Cardiovascular Agents/ad [Administration & Dosage]
KW  - *Drug-Eluting Stents
KW  - *Magnesium/ch [Chemistry]
KW  - *Paclitaxel/ad [Administration & Dosage]
KW  - *Percutaneous Coronary Intervention/is [Instrumentation]
KW  - Animals
KW  - Cardiovascular Agents/ch [Chemistry]
KW  - Cardiovascular Agents/me [Metabolism]
KW  - Coronary Angiography
KW  - Coronary Vessels/de [Drug Effects]
KW  - Coronary Vessels/ra [Radiography]
KW  - Feasibility Studies
KW  - Female
KW  - Fibrosis
KW  - Kinetics
KW  - Male
KW  - Materials Testing
KW  - Models, Animal
KW  - Molecular Weight
KW  - Neointima
KW  - Paclitaxel/ch [Chemistry]
KW  - Paclitaxel/me [Metabolism]
KW  - Polyglactin 910/ch [Chemistry]
KW  - Prosthesis Design
KW  - Swine
KW  - Swine, Miniature
KW  - MedStar Heart & Vascular Institute
KW  - Comparative Study
KW  - Journal Article
KW  - Research Support, Non-U.S. Gov't
N2  - AIMS: Among three versions of bioresorbable magnesium scaffolds featuring different paclitaxel-elution kinetics, we determined the best-performing scaffold and compared it with established, paclitaxel-eluting, permanent stents TAXUS Liberte and eucaTAX; CONCLUSIONS: By selecting suitable paclitaxel-elution kinetics, it was feasible to develop a bioresorbable magnesium scaffold whose efficacy and healing characteristics in a porcine coronary model are comparable with those of established paclitaxel-eluting permanent metallic stents; METHODS AND RESULTS: Drug-elution kinetics in magnesium scaffolds were modulated by varying the composition of their bioresorbable poly(lactide-co-glycolide) coating loaded with paclitaxel. A 50:50 ratio of lactide to glycolide, or an 85:15 ratio and either high- or low-molecular-weight polymer was applied in the "50/50", "85/15H", and "85/15L" scaffolds, respectively. Seventy-three magnesium scaffolds (25 50/50, 24 85/15H, 24 85/15L) and 36 control stents (18 TAXUS Liberte, 18 eucaTAX) were implanted in coronary arteries of 50 Yucatan mini-pigs. Angiography, histomorphometry, and histopathology data were acquired at 28, 90 and 180 days. The best-performing magnesium scaffold, 85/15H, was equivalent to TAXUS Liberte and superior to eucaTAX regarding late luminal loss, intimal area, fibrin score, and endothelialisation. Intimal inflammation score was higher in 85/15H than in the control stents at 28 days, but this effect disappeared at later time points
UR  - http://dx.doi.org/10.4244/EIJV8I12A218
ER  -