TY  - BOOK
AU  - Howard, Barbara V
AU  - Zhu, Jianhui
TI  - Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study
SN  - 0741-0395
PY  - 2013///
KW  - *Antibodies, Bacterial/bl [Blood]
KW  - *Antibodies, Viral/bl [Blood]
KW  - *Coronary Artery Disease/ge [Genetics]
KW  - *Health Surveys
KW  - *Indians, North American/ge [Genetics]
KW  - *Infection/ge [Genetics]
KW  - *Infection/im [Immunology]
KW  - Adolescent
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Alaska
KW  - C-Reactive Protein/an [Analysis]
KW  - Chlamydophila pneumoniae/im [Immunology]
KW  - Chlamydophila pneumoniae/ip [Isolation & Purification]
KW  - Chromosomes, Human, Pair 15/ge [Genetics]
KW  - Chronic Disease
KW  - Coronary Artery Disease/mi [Microbiology]
KW  - Coronary Artery Disease/vi [Virology]
KW  - Cytomegalovirus/im [Immunology]
KW  - Cytomegalovirus/ip [Isolation & Purification]
KW  - Female
KW  - Genetic Linkage/ge [Genetics]
KW  - Genetic Predisposition to Disease/ge [Genetics]
KW  - Genome, Human/ge [Genetics]
KW  - Helicobacter pylori/im [Immunology]
KW  - Helicobacter pylori/ip [Isolation & Purification]
KW  - Herpesvirus 1, Human/im [Immunology]
KW  - Herpesvirus 1, Human/ip [Isolation & Purification]
KW  - Herpesvirus 2, Human/im [Immunology]
KW  - Herpesvirus 2, Human/ip [Isolation & Purification]
KW  - Humans
KW  - Immunoglobulin G/bl [Blood]
KW  - Infection/mi [Microbiology]
KW  - Infection/vi [Virology]
KW  - Lod Score
KW  - Male
KW  - Middle Aged
KW  - Pedigree
KW  - Seroepidemiologic Studies
KW  - Serologic Tests
KW  - Time Factors
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N2  - This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved.  2013 WILEY PERIODICALS, INC
UR  - http://dx.doi.org/10.1002/gepi.21745
ER  -