TY  - BOOK
AU  - Walitt, Brian
TI  - Gene expression profiles of fatigued fibromyalgia patients with different categories of pain and catastrophizing: a preliminary report
SN  - 0029-6554
PY  - 2013///
KW  - *Catastrophization/ge [Genetics]
KW  - *Fatigue/ge [Genetics]
KW  - *Fibromyalgia/ge [Genetics]
KW  - *Pain/ge [Genetics]
KW  - Adult
KW  - Female
KW  - Gene Expression Profiling
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Middle Aged
KW  - Oligonucleotide Array Sequence Analysis
KW  - MedStar Washington Hospital Center
KW  - Medicine/Rheumatology
KW  - Comparative Study
KW  - Journal Article
KW  - Research Support, N.I.H., Intramural
KW  - Research Support, Non-U.S. Gov't
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - BACKGROUND: Fibromyalgia (FM) is a chronic condition characterized by diffused musculoskeletal pain and overwhelming fatigue; CONCLUSION: Findings provide preliminary evidence that specific physiological pathways may possibly delineate pain and catastrophizing mechanisms. Further investigation via the use of a larger and more homogenous sample is warranted. Published by Mosby, Inc; DISCUSSION: Differential expression of 107 genes between the high and low pain groups and 139 genes between the high and low catastrophizing groups (over 2.0-fold 20140821, p < .05) were observed. Network analyses showed interferon signaling and interferon regulatory activation factor pathways distinguished between the pain groups whereas dendritic cell maturation delineated between the catastrophizing groups; METHODS: Nine women with FM enrolled in an active Medstar Research Institute protocol were included in the gene expression analyses of peripheral blood RNA via Affymetrix GeneChip Human Genome U133 Plus 2.0 array (Santa Clara, CA). Scores from Brief Pain Inventory, Pain Catastrophizing Scale, and Multidimensional Fatigue Inventory categorized the nine participants into pain (high, n = 3; low, n = 6) and catastrophizing groups (high, n = 5; low, n = 4); PURPOSE: To compare the gene expression profiles of fatigued FM women with different levels of pain and catastrophizing
UR  - http://dx.doi.org/10.1016/j.outlook.2013.03.007
ER  -