TY  - BOOK
AU  - Driggers, Rita W
AU  - Singh, Jasbir
AU  - Timofeev, Julia
TI  - Spontaneous preterm birth in African-American and Caucasian women receiving 17alpha-hydroxyprogesterone caproate
SN  - 0735-1631
PY  - 2014///
KW  - *African Americans/sn [Statistics & Numerical Data]
KW  - *Estradiol Antagonists/tu [Therapeutic Use]
KW  - *European Continental Ancestry Group/sn [Statistics & Numerical Data]
KW  - *Hydroxyprogesterones/tu [Therapeutic Use]
KW  - *Premature Birth/eh [Ethnology]
KW  - *Premature Birth/pc [Prevention & Control]
KW  - Adolescent
KW  - Adult
KW  - Cervical Length Measurement
KW  - Cervix Uteri/ah [Anatomy & Histology]
KW  - Female
KW  - Gestational Age
KW  - Humans
KW  - Pregnancy
KW  - Pregnancy, High-Risk
KW  - Recurrence/pc [Prevention & Control]
KW  - Retrospective Studies
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Maternal-Fetal Medicine
KW  - Journal Article
N2  - CONCLUSION: Despite treatment with 17P, African-American women have higher rates of recurrent preterm birth. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA; OBJECTIVE: To determine if the rates of recurrent spontaneous preterm birth in women receiving 17alpha-hydroxyprogesterone caproate (17P) differ according to maternal race; RESULTS: African-American women initiated 17P injections later (19.6 versus 18.9 weeks, p<0.001) and discontinued injections earlier (33.2 versus 34.1 weeks, p<0.001) than Caucasian women. Spontaneous recurrent preterm birth<34 weeks was higher in African-Americans versus Caucasians receiving 17P (odds ratio 2.1; 95% confidence interval 1.7, 2.4). After adjusting for other significant factors, African-American race retained the strongest association with recurrent spontaneous preterm birth<34 weeks. Within each racial group, short cervical length<25mm before 27 weeks' gestation had the highest hazard of recurrent spontaneous preterm delivery; STUDY DESIGN: Retrospective analysis of a cohort of women enrolled in outpatient 17P administration at<27 weeks. Maternal characteristics, obstetric history, and rates of recurrent preterm birth were determined using chi-square and multivariable Cox proportional hazards regression at two-tailed alpha=0.05. Primary study outcome was defined as having a spontaneous preterm birth<34 weeks
UR  - http://dx.doi.org/10.1055/s-0033-1334452
ER  -