Ischemic preconditioning-an unfulfilled promise. [Review] - 2015

Available in print through MWHC library: 2002 - present

Myocardial reperfusion injury has been identified as a key determinant of myocardial infarct size in patients undergoing percutaneous or surgical interventions. Although the molecular mechanisms underpinning reperfusion injury have been elucidated, attempts at translating this understanding into clinical benefit for patients undergoing cardiac interventions have produced mixed results. Ischemic conditioning has been applied before, during, or after an ischemic insult to the myocardium and has taken the form of local induction of ischemia or ischemia of distant tissues. Clinical studies have confirmed the safety of differing conditioning techniques, but the benefit of such techniques in reducing hard clinical event rates has produced mixed results. The aim of this article is to review the role of ischemic conditioning in patients undergoing percutaneous and surgical coronary revascularization.Copyright � 2014 Elsevier Inc. All rights reserved.


English

1878-0938


*Angioplasty, Balloon, Coronary/mt [Methods]
*Coronary Artery Bypass/mt [Methods]
*Coronary Artery Disease/th [Therapy]
*Ischemic Preconditioning, Myocardial/mt [Methods]
*Myocardial Infarction/th [Therapy]
*Myocardial Reperfusion Injury/pc [Prevention & Control]
Angioplasty, Balloon, Coronary/ae [Adverse Effects]
Coronary Angiography/mt [Methods]
Coronary Artery Bypass/ae [Adverse Effects]
Coronary Artery Disease/ra [Radiography]
Female
Follow-Up Studies
Humans
Ischemic Preconditioning, Myocardial/ae [Adverse Effects]
Male
Myocardial Infarction/di [Diagnosis]
Needs Assessment
Patient Safety
Severity of Illness Index
Treatment Outcome


MedStar Heart & Vascular Institute


Comparative Study
Journal Article
Review