TY - BOOK AU - Bunning, Robert D AU - Kao, Cyrus TI - Two cases of metallosis from metal-on-polyethylene total hips: an emerging problem SN - 1934-1482 PY - 2015/// KW - *Cobalt/bl [Blood] KW - *Cobalt/to [Toxicity] KW - *Prosthesis Design KW - Aged, 80 and over KW - Arthroplasty, Replacement, Hip KW - Female KW - Hip Prosthesis/ae [Adverse Effects] KW - Humans KW - Male KW - Middle Aged KW - Polyethylene KW - MedStar National Rehabilitation Network KW - Case Reports KW - Journal Article N2 - This report describes 2 cases of metallosis from metal-on-polyethylene total hip replacements. Case 1 involved a Stryker rejuvenate implant, which has since been recalled. This patient had minimal symptoms, an elevated cobalt level, and loosening. The patient in case 2 had a Dupuys Pinnacle system, with symptoms of weakness, rash, and hip pain. Abnormal laboratory values include elevated sedimentation rate, C-reactive protein, creatinine, cobalt, and decreased hematocrit. Magnetic resonance imaging revealed synovial thickening and extracapsular edema. Although metallosis is a well-established complication of metal-on-metal implants, emerging data reveal that it also may be a problem in non-metal-on-metal implants such as either metal-on-polyethylene or ceramic-on-polyethylene implants, perhaps related to modular corrosion. Copyright © 2015 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved UR - http://dx.doi.org/10.1016/j.pmrj.2014.11.004 ER -