TY  - BOOK
AU  - Atkins, Michael
AU  - Fishbein, Thomas M
AU  - Satoskar, Rohit
TI  - Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC
SN  - 2326-6066
PY  - 2016///
KW  - *Antigens, CD3/me [Metabolism]
KW  - *Carcinoma, Hepatocellular/im [Immunology]
KW  - *CD8-Positive T-Lymphocytes/im [Immunology]
KW  - *Liver Neoplasms/im [Immunology]
KW  - *Lymphocytes, Tumor-Infiltrating/im [Immunology]
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Antigens, CD274/me [Metabolism]
KW  - Biomarkers, Tumor/me [Metabolism]
KW  - Carcinoma, Hepatocellular/di [Diagnosis]
KW  - Carcinoma, Hepatocellular/pa [Pathology]
KW  - Carcinoma, Hepatocellular/su [Surgery]
KW  - Disease-Free Survival
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Kaplan-Meier Estimate
KW  - Liver Neoplasms/di [Diagnosis]
KW  - Liver Neoplasms/pa [Pathology]
KW  - Liver Neoplasms/su [Surgery]
KW  - Male
KW  - Middle Aged
KW  - Neoplasm Invasiveness
KW  - Neoplasm Proteins/me [Metabolism]
KW  - Neoplasm Staging
KW  - Prognosis
KW  - Recurrence
KW  - Risk Factors
KW  - T-Lymphocyte Subsets/im [Immunology]
KW  - MedStar Washington Hospital Center
KW  - Washington Cancer Institute
KW  - Georgetown Transplant Institute
KW  - Surgery/Transplantation
KW  - Journal Article
N2  - Copyright ©2016 American Association for Cancer Research; Immune cells that infiltrate a tumor may be a prognostic factor for patients who have had surgically resected hepatocellular carcinoma (HCC). The density of intratumoral total (CD3(+)) and cytotoxic (CD8(+)) T lymphocytes was measured in the tumor interior and in the invasive margin of 65 stage I to IV HCC tissue specimens from a single cohort. Immune cell density in the interior and margin was converted to a binary score (0, low; 1, high), which was correlated with tumor recurrence and relapse-free survival (RFS). In addition, the expression of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) was correlated with the density of CD3(+) and CD8(+) cells and clinical outcome. High densities of both CD3(+) and CD8(+) T cells in both the interior and margin, along with corresponding Immunoscores, were significantly associated with a low rate of recurrence (P = 0.007) and a prolonged RFS (P = 0.002). In multivariate logistic regression models adjusted for vascular invasion and cellular differentiation, both CD3(+) and CD8(+) cell densities predicted recurrence, with odds ratios of 5.8 [95% confidence interval (CI), 1.6-21.8] for CD3(+) and 3.9 (95% CI, 1.1-14.1) for CD8(+) Positive PD-L1 staining was correlated with high CD3 and CD8 density (P = 0.024 and 0.005, respectively) and predicted a lower rate of recurrence (P = 0.034), as well as prolonged RFS (P = 0.029). Immunoscore and PD-L1 expression, therefore, are useful prognostic markers in patients with HCC who have undergone primary tumor resection. Cancer Immunol Res; 4(5); 419-30. ©2016 AACR.
UR  - https://dx.doi.org/10.1158/2326-6066.CIR-15-0110
ER  -