TY  - BOOK
AU  - Grantz, Katherine L
AU  - Huang, Chun Chih
AU  - Iqbal, Sara N
AU  - Kawakita, Tetsuya
AU  - Landy, Helain J
AU  - Reddy, Uma M
TI  - Duration of Oxytocin and Rupture of the Membranes Before Diagnosing a Failed Induction of Labor
SN  - 0029-7844
PY  - 2016///
KW  - *Extraembryonic Membranes
KW  - *Labor, Induced
KW  - *Labor, Obstetric
KW  - *Oxytocics/ad [Administration & Dosage]
KW  - *Oxytocin/ad [Administration & Dosage]
KW  - Adult
KW  - Chorioamnionitis/ep [Epidemiology]
KW  - Endometritis/ep [Epidemiology]
KW  - Female
KW  - Humans
KW  - Infant, Newborn
KW  - Intensive Care, Neonatal/sn [Statistics & Numerical Data]
KW  - Labor, Obstetric/de [Drug Effects]
KW  - Parity
KW  - Pregnancy
KW  - Retrospective Studies
KW  - Time Factors
KW  - Treatment Failure
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Maternal-Fetal Medicine
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSION: Based on when neonatal morbidity increased, in an otherwise uncomplicated induction of labor with rupture of membranes, a latent phase after initiation of oxytocin of at least 12 hours for nulliparous women and 15 hours in multiparous women is a reasonable criterion for diagnosing a failed induction; METHODS: This is a retrospective cohort study using data from the Consortium of Safe Labor study, including 9,763 nulliparous and 8,379 multiparous women with singleton, term pregnancies undergoing induction at 2 cm dilation or less with rupture of membranes before 6 cm dilation after which the latent phase ended. Outcomes were evaluated according to duration of oxytocin and rupture of membranes; OBJECTIVE: To compare maternal and neonatal outcomes based on length of the latent phase during induction with rupture of membranes before 6 cm dilation; RESULTS: At time points from 6 to 18 hours of oxytocin and rupture of membranes, the rates of nulliparous women remaining in the latent phase declined (35.9-1.4%) and the rates of vaginal delivery for those remaining in the latent phase at these time periods decreased (54.1-29.9%) Nulliparous women remaining in the latent phase for 12 hours compared with women who had exited the latent phase had significantly increased rates of chorioamnionitis (12.1% compared with 4.1%) and endometritis (3.6% compared with 1.3%) and increased rates of neonatal intensive care unit admission (8.7% compared with 6.3%). Similar patterns were present for multiparous women at 15 hours
UR  - https://dx.doi.org/10.1097/AOG.0000000000001527
ER  -