TY  - BOOK
AU  - Fishbein, Dawn
AU  - Ghidey, Fisseha Y
AU  - Igbinosa, Osamuyimen
AU  - Lai, Leon
AU  - Lowery, Robert C
AU  - Mills, Kristin
AU  - Ruiz, Maria E
AU  - Woods, Christian J
AU  - Wortmann Glenn W
TI  - Case series of Bartonella quintana blood culture-negative endocarditis in Washington, DC
SN  - 2053-3721
PY  - 2016///
KW  - PubMed-not-MEDLINE -- Not indexed
KW  - MedStar Washington Hospital Center
KW  - Medicine/Infectious Diseases
KW  - Journal Article
N2  - CASE PRESENTATION: We constructed a descriptive case series from a retrospective review of medical records from April to December 2013 at an 800-bed urban hospital. All three patients (ages: 52, 55 and 57 years) were undomiciled/homeless men with a history of alcoholism. Although they had negative blood cultures, echocardiography demonstrated aortic/mitral valve perforation and regurgitation in one patient, aortic/mitral valve vegetation with mitral regurgitation in the second patient, and aortic valve vegetation with regurgitation in the third patient. The patients had positive Bartonella quintana serum immunoglobulin G (IgG) with negative immunoglobulin M (IgM). PCR on DNA extracted from cardiac valves was positive for Bartonella, and DNA sequencing of PCR amplicons identified Bartonella quintana. Patients received treatment with doxycycline/rifampin or doxycycline/gentamicin; CONCLUSION: Clinicians should consider Bartonella endocarditis as a differential diagnosis in patients who fit elements of the Duke Criteria, as well as having a history of homelessness and alcoholism; INTRODUCTION: Prior studies (predominantly from Europe) have demonstrated blood culture-negative endocarditis due to Bartonella. Our objective was to describe three cases of Bartonella quintana endocarditis identified within one year at a large hospital in Washington, DC, USA
UR  - https://dx.doi.org/10.1099/jmmcr.0.005049
ER  -