TY  - BOOK
AU  - Sugarbaker, Paul H
TI  - Peritoneal metastases from colorectal cancer in the absence of lymph node metastases show a high survival rate despite unfavorable prognostic indicators
SN  - 0748-7983
PY  - 2022///
KW  - *Colorectal Neoplasms
KW  - *Hyperthermia, Induced
KW  - *Peritoneal Neoplasms
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Colorectal Neoplasms/pa [Pathology]
KW  - Combined Modality Therapy
KW  - Cytoreduction Surgical Procedures/ae [Adverse Effects]
KW  - Female
KW  - Humans
KW  - Hyperthermia, Induced/ae [Adverse Effects]
KW  - Lymphatic Metastasis
KW  - Male
KW  - Middle Aged
KW  - Peritoneal Neoplasms/sc [Secondary]
KW  - Prognosis
KW  - Retrospective Studies
KW  - Survival Rate
KW  - Young Adult
KW  - Washington Cancer Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:2002-2007
N2  - BACKGROUND: Patients with colorectal cancer die as a result of metastases to liver, lymph nodes or the peritoneal surfaces. The primary is almost always controlled by colon or rectal cancer resection; CONCLUSIONS: In this restricted group of lymph node negative colorectal PM patients with a complete cytoreduction, a high PCI or the presence of signet ring cells should not exclude patients from CRS and perioperative chemotherapy. Copyright © 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved; METHODS: Consecutive patients with isolated metastases to peritoneal surfaces (no lymph node, liver or systemic metastases) were referred to the Washington Cancer Institute from all over the United States and abroad. The study of this particular group of patients was to determine the impact of clinical and histologic features on overall survival. These variables were collected from the primary colorectal cancer resection performed at the referring institute and from the cytoreductive surgery (CRS) performed at the Washington Hospital Center. The data was prospectively accumulated and retrospectively analyzed; RESULTS: Thirty-one consecutive patients had a complete cytoreduction. This restricted cohort of patients was studied in an attempt to eliminate confounding variables. The median age was 47 years (range 19-80). There were 14 (45%) males. The median overall survival following CRS was 67.9 months with a 5-year and 10-year survival of 51.9% and 43.6%, respectively. None of the clinical or histologic features, including peritoneal cancer index (PCI) and presence of signet ring cells, significantly predicted survival except for carbohydrate antigen 19-9 (CA19-9) (p = 0.0033). None of the involved abdominopelvic regions predicted a guarded outcome
UR  - https://dx.doi.org/10.1016/j.ejso.2022.02.001
ER  -