TY  - BOOK
AU  - Wartofsky, Leonard
TI  - Thyroid hemiagenesis: incidence, clinical significance and genetic background
SN  - 0021-972X
PY  - 2017///
KW  - *Genetic Background
KW  - *Genetic Predisposition to Disease/ep [Epidemiology]
KW  - *Thyroid Dysgenesis/ep [Epidemiology]
KW  - *Thyroid Dysgenesis/pa [Pathology]
KW  - Animals
KW  - DNA-Binding Proteins/ge [Genetics]
KW  - Female
KW  - Humans
KW  - Incidence
KW  - Male
KW  - Mice
KW  - Mutation
KW  - PAX8 Transcription Factor/ge [Genetics]
KW  - Prognosis
KW  - Proteasome Endopeptidase Complex/ge [Genetics]
KW  - Rare Diseases
KW  - Risk Assessment
KW  - Severity of Illness Index
KW  - Thyroid Dysgenesis/dg [Diagnostic Imaging]
KW  - Thyroid Dysgenesis/dt [Drug Therapy]
KW  - Thyroid Function Tests
KW  - Thyroid Neoplasms/ge [Genetics]
KW  - Thyroid Neoplasms/pa [Pathology]
KW  - Thyroxine/tu [Therapeutic Use]
KW  - Ultrasonography, Doppler/mt [Methods]
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Journal Article
N1  - Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006
N2  - Conclusions: Patients with THA are prone to develop additional thyroid pathologies and theoretically might benefit from L-thyroxine treatment in order to lower the thyrotropin levels to that observed in the normal population. However, further research should be done to ascertain whether such intervention early in life would prevent development of associated thyroid conditions. At least, increased vigilance should be maintained to reveal all the concomitant disorders as soon as possible during follow-up examinations. Application of high-throughput technologies enabling a genome wide search for novel factors involved in thyroid embryogenesis, may be the next step to expand the knowledge on THA pathogenesis; Context: Thyroid hemiagenesis (THA) constitutes a rare, congenital disorder that is characterized by an absence of one thyroid lobe. Because the pathogenesis and clinical significance of this malformation remain undefined, specific clinical recommendations are lacking, especially for asymptomatic cases; Evidence Acquisition: The PubMed Database was searched (years 1970-2017) and the following terms were used to retrieve the results: "thyroid hemiagenesis", "thyroid hemiaplasia", "one thyroid lobe agenesis" and "one thyroid lobe aplasia". Subsequently, reference sections of the retrieved articles were searched; Evidence Synthesis: There is a noticeable susceptibility of THA subjects to develop additional thyroid and non-thyroidal pathologies. In pathogenesis of concomitant thyroid pathologies, a chronic elevation in TSH values may play an important role. So far genetic studies failed to find a common genetic background of the anomaly and potential underlying cause was identified in minority of cases
UR  - https://dx.doi.org/10.1210/jc.2017-00784
ER  -