TY - BOOK AU - Grantz, Katherine L TI - Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study SN - 0091-6765 PY - 2017/// KW - *Climate Change KW - *Environmental Exposure/sn [Statistics & Numerical Data] KW - *Stillbirth/ep [Epidemiology] KW - *Temperature KW - Stress, Physiological KW - United States/ep [Epidemiology] KW - MedStar Washington Hospital Center KW - Obstetrics and Gynecology/Maternal-Fetal Medicine KW - Journal Article KW - Multicenter Study N1 - Available online from MWHC library: 1972 - present N2 - BACKGROUND: Climate change is expected to have adverse health effects, but the association between extreme ambient temperatures and stillbirth is unclear; CONCLUSIONS: Extremes of local ambient temperature may have chronic and acute effects on stillbirth risk, even in temperate zones. Temperature-related effects on pregnancy outcomes merit additional investigation. https://doi.org/10.1289/EHP945; METHODS: We linked 223,375 singleton births of gestation (2002-2008) from 12 U.S. sites to local temperature. Chronic exposure to hot (), cold (), or mild () temperatures was defined using window- and site-specific temperature distributions for three-months preconception, first and second trimester, and whole-pregnancy averages. For acute exposure, average temperature for the week preceding delivery was compared to two alternative control weeks in a case-crossover analysis; OBJECTIVES: We investigated acute and chronic associations between extreme ambient temperatures and stillbirth risk, and estimated the attributable risk associated with local temperature extremes in the United States; RESULTS: In comparison with mild, whole-pregnancy exposure to cold [adjusted odds ratio (aOR) = 4.75; 95% confidence interval (CI): 3.95, 5.71] and hot (aOR = 3.71; 95% CI: 3.07, 4.47) were associated with stillbirth risk, and preconception and first and second trimester exposures were not. Approximately 17-19% of stillbirth cases were potentially attributable to chronic whole-pregnancy exposures to local temperature extremes. This is equivalent to and excess cases in the United States annually. In the case-crossover analysis, a 1degreeC increase during the week preceding delivery was associated with a increase in stillbirth risk during the warm season (May-September). This incidence translates to additional stillbirths per 10,000 births for each 1degreeC increase UR - https://dx.doi.org/10.1289/EHP945 ER -