TY  - BOOK
AU  - Azzouqa, Alaa
AU  - Ben-Dor, Itsik
AU  - Kim, Jae I
AU  - Koiffman, Edward
AU  - Lindsay, Joseph
AU  - Pichard, Augusto D
AU  - Satler, Lowell F
AU  - Torguson, Rebecca
AU  - Waksman, Ron
AU  - Wang, Zuyue
AU  - Weissman, Gaby
TI  - Patient characteristics in variable left ventricular recovery from Takotsubo syndrome
SN  - 1878-0938
PY  - 2018///
KW  - *Stroke Volume
KW  - *Takotsubo Cardiomyopathy/pp [Physiopathology]
KW  - *Ventricular Function, Left
KW  - Action Potentials
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Comorbidity
KW  - Echocardiography
KW  - Electrocardiography
KW  - Female
KW  - Heart Rate
KW  - Humans
KW  - Hypothyroidism/ep [Epidemiology]
KW  - Male
KW  - Middle Aged
KW  - Prevalence
KW  - Recovery of Function
KW  - Registries
KW  - Retrospective Studies
KW  - Takotsubo Cardiomyopathy/di [Diagnosis]
KW  - Takotsubo Cardiomyopathy/ep [Epidemiology]
KW  - Takotsubo Cardiomyopathy/th [Therapy]
KW  - Time Factors
KW  - United States/ep [Epidemiology]
KW  - MedStar Heart & Vascular Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
N1  - Available in print through MWHC library: 2002 - present
N2  - BACKGROUND: Takotsubo syndrome (TTS) is a heart failure syndrome which is usually reversible. Factors associated with degree of recovery of left ventricular systolic function in TTS are poorly understood; CONCLUSION: Takotsubo patients with partial myocardial recovery were older, presented with longer QT intervals, and were more likely to have comorbid hypothyroidism; Copyright (c) 2017 Elsevier Inc. All rights reserved; MATERIALS AND METHODS: We conducted a retrospective analysis of 90 TTS patients treated at our institution from 2006 to 2014. Patients were grouped based on recovery of left ventricular ejection fraction (LVEF) on follow-up transthoracic echocardiogram as left ventricular ejection fraction <50% (partial group) or preserved ejection fraction >=50% (full group). Patient baseline characteristics, comorbidities, biomarkers, electrocardiography, and echocardiogram were collected. We also compared adverse events that occurred during hospitalization; RESULTS: In comparison to full recovery group patients (n=63), partial recovery patients (n=27) were older (76.9+/-13 vs. 70.6+/-13years; P=0.02) and had a higher prevalence of comorbid hypothyroidism (26% vs. 8%; P=0.02). A greater number of patients from the partial group were also taking levothyroxine replacement (22% vs. 3%; P=0.003). We found no significant between-group differences in type of triggering event or cardiac biomarker levels. QT interval was longer in the partial group (540.6+/-71msec vs. 460.7+/-35msec; P=0.01). Follow-up LVEF was 37.9+/-8% in the partial group and 58.0+/-4% in the full group (P<0.001). There were no statistically significant differences in length of stay or adverse events
UR  - https://dx.doi.org/10.1016/j.carrev.2017.10.002
ER  -