TY  - BOOK
AU  - Burman, Kenneth D
AU  - Carroll, Nancy M
AU  - Felger, Erin A
AU  - Jonklaas, Jacqueline
AU  - Krishnan, Jayashree
TI  - Novel biomarker SYT12 may contribute to predicting papillary thyroid cancer outcomes
SN  - 2056-5623
PY  - 2018///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Pathology
KW  - Surgery/Endocrine Surgery
KW  - Surgery/General Surgery
KW  - Journal Article
N2  - Aim: To investigate biomarkers for predicting papillary thyroid cancer outcomes; Conclusion: SYT12 has some prognostic significance in papillary thyroid cancer. Further validation studies in larger populations are warranted; Materials & methods: The expression of biomarkers (ITGA2, SYT12 and CDH3) was studied in a prospective cohort of patients with papillary thyroid cancer. Three outcomes of initial metastases, baseline status and longitudinal status were analyzed and correlated with the biomarkers; Results: SYT12 provided the best prediction of initial metastasis (sensitivity: 72%; specificity: 54%). SYT12 had the highest accuracy for predicting longitudinal status (sensitivity: 100%; specificity: 47%). The best performance for longitudinal status resulted from combining SYT12 with American Thyroid Association risk stratification, with sensitivity and specificity of 88 and 73%, respectively
UR  - https://dx.doi.org/10.4155/fsoa-2017-0087
ER  -