Emergency department approach to QTc prolongation. [Review] 

 -  2017 
<br/><br/>Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006 
<br/><br/> QTc prolongation has been associated with increased risk of developing ventricular tachydysrhythmias, particularly Torsades de Pointes (TdP). QTc prolongation is influenced by many factors including congenital causes, heart rate, metabolic imbalances, and pharmacotherapy. Several commonly used medications in the emergency department (ED), such as antipsychotics and antiemetics, are known to prolong the QT interval. In addition, ED patients may present with conditions that may predispose them to QTc prolongation, such as drug overdose or hypokalemia, which can further complicate management. ED providers should not only be aware of which medications have these effects, but must also thoroughly investigate any pertinent patient history that may contribute to QTc prolongation. This review discusses commonly encountered medications that are associated with QTc prolongation, the mechanisms by which they prolong the QTc interval, and other factors that may influence ED medication administration and management. Copyright (c) 2017 Elsevier Inc. All rights reserved. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0735-6757 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Anti-Bacterial Agents/ae [Adverse Effects]<br/>*Antiemetics/ae [Adverse Effects]<br/>*Antipsychotic Agents/ae [Adverse Effects]<br/>*Emergency Service, Hospital<br/>*Long QT Syndrome/di [Diagnosis]<br/>*Torsades de Pointes/di [Diagnosis]<br/>Drug Overdose/co [Complications]<br/>Drug Overdose/pp [Physiopathology]<br/>Electrocardiography<br/>Guideline Adherence<br/>Humans<br/>Long QT Syndrome/ci [Chemically Induced]<br/>Practice Patterns, Physicians'<br/>Risk Factors<br/>Torsades de Pointes/ci [Chemically Induced]<br/>United States/ep [Epidemiology]
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Emergency Medicine
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article<br/>Review