TY  - BOOK
AU  - Lessin, Lawrence S
TI  - Platelet count and total and cause-specific mortality in the Women's Health Initiative
SN  - 1047-2797
PY  - 2017///
KW  - *Cause of Death
KW  - *Mortality
KW  - *Platelet Count
KW  - Aged
KW  - Coronary Disease/bl [Blood]
KW  - Coronary Disease/mo [Mortality]
KW  - Female
KW  - Humans
KW  - Middle Aged
KW  - Neoplasms/bl [Blood]
KW  - Neoplasms/mo [Mortality]
KW  - Platelet Count/sn [Statistics & Numerical Data]
KW  - Proportional Hazards Models
KW  - Women's Health/sn [Statistics & Numerical Data]
KW  - Washington Cancer Institute
KW  - Journal Article
N2  - CONCLUSIONS: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality; Copyright (c) 2017 Elsevier Inc. All rights reserved; METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count; PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality; RESULTS: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers
UR  - https://dx.doi.org/10.1016/j.annepidem.2017.02.001
ER  -