Dual antithrombotic plus adjunctive antiinflammatory therapy to improve cardiovascular outcome in atrial fibrillation patients with concurrent acute coronary syndrome: A triple-pathway strategy. - 2018

Copyright (c) 2018 Elsevier Ltd. All rights reserved. The concurrence of atrial fibrillation and acute coronary syndrome poses a conundrum in the antithrombotic management as intensification of anticoagulation or antiplatelet therapy inevitably comes at the price of an increased bleeding risk. Various antithrombotic combinations have been attempted to prevent the recurrent cardiovascular events, however, there has been limited success in effective risk reduction for this high risk population. Given the overarching effect of interleukin 1beta-driven inflammation on the arrhythmogenesis, thrombogenesis, and hypercoagulability, we hypothesize that the triple-pathway strategy (i.e., incorporating antiinflammatory therapy into anticoagulant and antiplatelet therapy) would grant incremental cardiovascular benefits for atrial fibrillation patients with coexisting acute coronary syndrome and stent placement.


English

0306-9877

10.1016/j.mehy.2018.02.036 [doi] S0306-9877(17)31218-5 [pii]


*Acute Coronary Syndrome/dt [Drug Therapy]
*Anti-Inflammatory Agents/ad [Administration & Dosage]
*Atrial Fibrillation/dt [Drug Therapy]
*Fibrinolytic Agents/ad [Administration & Dosage]
Acute Coronary Syndrome/co [Complications]
Anticoagulants/ae [Adverse Effects]
Arrhythmias, Cardiac/dt [Drug Therapy]
Aspirin/tu [Therapeutic Use]
Atrial Fibrillation/co [Complications]
Cardiovascular System
Comorbidity
Drug Therapy, Combination
Hemorrhage/ci [Chemically Induced]
Humans
Interleukin-1beta/me [Metabolism]
Models, Theoretical
Platelet Aggregation Inhibitors
Randomized Controlled Trials as Topic
Stents
Stroke/co [Complications]
Warfarin/tu [Therapeutic Use]


MedStar Union Memorial Hospital


Medicine


Journal Article