TY - BOOK AU - De Freitas, S AU - Woo, E Y TI - Ultrasound-guided foam sclerotherapy as a therapeutic modality in venous ulceration. [Review] SN - 1479-666X PY - 2022/// KW - *Varicose Ulcer KW - *Varicose Veins KW - Humans KW - Prospective Studies KW - Recurrence KW - Saphenous Vein KW - Sclerotherapy/ae [Adverse Effects] KW - Sclerotherapy/mt [Methods] KW - Treatment Outcome KW - Ulcer/et [Etiology] KW - Ultrasonography, Interventional KW - Varicose Ulcer/dg [Diagnostic Imaging] KW - Varicose Ulcer/et [Etiology] KW - Varicose Ulcer/th [Therapy] KW - Varicose Veins/et [Etiology] KW - MedStar Heart & Vascular Institute KW - Journal Article KW - Meta-Analysis KW - Review KW - Systematic Review N2 - CONCLUSION: A prospective, trial is warranted in order to determine the true merits of UGFS in the setting of venous ulceration. Copyright © 2021 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved; METHODS: The MEDLINE, CENTRAL and Embase databases were used to search for relevant studies using the terms ' (sclerotherapy AND ulcer) OR (vein AND ulcer) OR (sclerotherapy AND vein)'. Heterogeneity between studies was quantified using the I2 statistic. A random effects model was used to calculate risk ratios where substantial heterogeneity was found; OBJECTIVES: The objective of this systematic review and meta-analysis was to evaluate rates of ulcer healing following ultrasound-guided foam sclerotherapy (UGFS); RESULTS: The initial search yielded 8266 articles. 8 studies were included in the qualitative synthesis and 3 in the meta-analysis. Superior complete ulcer healing rates were noted in patients treated with foam sclerotherapy versus compression therapy alone (pooled OR 6.41, 95% CI = 0.3-148.2, p = 0.246, random effects method). A marked degree of heterogeneity was observed between studies (I2 = 81%) UR - https://dx.doi.org/10.1016/j.surge.2021.08.008 ER -