TY  - BOOK
AU  - Burman, Kenneth D
AU  - Van Nostrand, Douglas
AU  - Wartofsky, Leonard
AU  - Ylli, Dorina
TI  - Eliminating the Age Cutoff in Staging of Differentiated Thyroid Cancer: The Safest Road?
SN  - 0021-972X
PY  - 2018///
KW  - *Adenocarcinoma, Follicular/pa [Pathology]
KW  - *Aging/ph [Physiology]
KW  - *Carcinoma, Papillary/pa [Pathology]
KW  - *Neoplasm Staging/st [Standards]
KW  - *Thyroid Neoplasms/pa [Pathology]
KW  - Age Factors
KW  - Diagnostic Techniques, Endocrine/st [Standards]
KW  - Humans
KW  - Neoplasm Staging/mt [Methods]
KW  - Prognosis
KW  - Reference Values
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Medicine/Nuclear Medicine
KW  - Journal Article
N1  - Available online through MWHC library: 1999- June 2013, Available in print through MWHC library: 1999 - 2006
N2  - Background: Unlike virtually all other cancer types, thyroid cancer is unique in that patient age is a key component in its staging. Pathologists and clinicians worldwide have accepted an age cutoff of 45 years for staging; in 2018, this advances to age 55 years in the eighth edition of the American Joint Commission on Cancer staging system; Conclusions: Among all cancers, age has an important role in only thyroid cancer staging. The consideration of age as a continuous variable and the search for age-associated prognostic variables could elucidate a more accurate staging system; Evidence Acquisition: Clinical and basic research studies, reviews, and previous editions of consensus statements regarding thyroid cancer staging were reviewed, with particular focus on the influence of age in thyroid cancer prognosis; Evidence Synthesis: The majority of findings report an association of age with thyroid cancer survival but do not support a specific age cutoff; rather, they suggest that outcome is affected by age as a continuous variable. Conceivably, other factors interact with age on a continuous basis over time, affecting prognosis. When identified, these factors could alter our current concept of the importance of an age cutoff in staging; Purpose: This perspective briefly reviews the basis for this practice and challenges it as no more appropriate than for other malignancies
UR  - https://dx.doi.org/10.1210/jc.2017-02725
ER  -