02540nam a22004457a 4500
180706s20182018 xxu||||| |||| 00| 0 eng d
0007-5027
10.1093/labmed/lmy025 [doi]
5036164 [pii]
Ovid MEDLINE(R)
29897485
Severe Underestimation of Serum Na following IVIG Treatment.
Laboratory Medicine. 49(4):372-376, 2018 Oct 11.
Lab Med. 49(4):372-376, 2018 Oct 11.
Laboratory medicine
2018
FY2019
2018-07-06
FY2018
Current chemistry analyzers measure ion concentration using ion- selective electrodes; however, may differ in the specific technology at the bedside versus the central laboratory. Instruments utilized for point-of-care testing (POCT) at the bedside use direct ion-selective electrodes, whereas central-laboratory analyzers use indirect ion-selective electrodes. Under most circumstances, these instruments will deliver the same result; however, various substances can cause interferences in one or the other. An 18-year-old Hispanic woman with a history of immune thrombocytopenic purpura (ITP) presented at Children's National Medical Center (CNMC) with a severe headache and required intravenous immunoglobulin (IVIG) therapy. Because a discrepancy developed between her point-of-care and central-laboratory sodium values, another instrument was used to retest the central-laboratory plasma specimens. The results were more in agreement with those from the point-of-care instrument and revealed a unique interference in sodium measurement related to IVIG use.
English
*Immunoglobulins, Intravenous/tu [Therapeutic Use]
*Purpura, Thrombocytopenic, Idiopathic/bl [Blood]
*Purpura, Thrombocytopenic, Idiopathic/dt [Drug Therapy]
*Sodium/bl [Blood]
Adolescent
Diagnostic Errors
Female
Humans
Purpura, Thrombocytopenic, Idiopathic/di [Diagnosis]
Purpura, Thrombocytopenic, Idiopathic/pp [Physiopathology]
Reproducibility of Results
MedStar Washington Hospital Center
Pathology
Journal Article
Virk, Mrigender S
Dean NP, Virk MS, Wong ECC
https://dx.doi.org/10.1093/labmed/lmy025
https://dx.doi.org/10.1093/labmed/lmy025
ART
Article
0
0
0
0
Article
authcat
authcat
2018-07-06
0
29897485
29897485
2018-07-06
2018-07-06
ART
3512
3512