TY  - BOOK
AU  - Case, Brian C
AU  - Di Mario, Carlo
AU  - Garcia-Garcia, Hector M
AU  - Mintz, Gary S
AU  - Shea, Corey
AU  - Waksman, Ron
AU  - Zhang, Cheng
TI  - Correlation between lipidic content and arterial-wall plaque burden: A Lipid Rich Plaque study sub-analysis
SN  - 0167-5273
PY  - 2022///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - BACKGROUND: Large plaque burden (PB) has been linked to adverse coronary events. We sought to assess the correlation between lipidic content and arterial PB within the Lipid Rich Plaque (LRP) study; CLINICAL TRIAL REGISTRATION: The Lipid-Rich Plaque Study (LRP), NCT02033694, https://clinicaltrials.gov/ct2/show/NCT02033694. Copyright © 2022 Elsevier B.V. All rights reserved; CONCLUSIONS: Coronary segments with high lipid content but no measurable PB were still associated with events at 2 years. NC-MACE vulnerability increased as the lipidic content and PB increased, with the highest incidence within segments having maxLCBI4mm > 400 and plaque >40%; METHODS: This analysis included 1269 patients and 5743 coronary segments with both evaluable Lipid Core Burden Index (maxLCBI4mm) and PB. Non-culprit major adverse cardiac events (NC-MACE; defined as a composite of cardiac death, cardiac arrest, non-fatal myocardial infarction, acute coronary syndrome, revascularization, and hospital readmission for angina with progressive stenosis) were assessed by hazard ratios (HR) at 2 years; RESULTS: NC-MACE for segment cohorts in the most vulnerable quadrant of maxLCBI4mm > 400 and PB >40% was the highest (HR, 3.78 [95% confidence interval (CI) 2.39-5.66]) with similar rates for just PB >40% (HR 1.31 [95% CI 0.81-2.02]) and just maxLCBI4mm > 400 (HR 1.11 [95% CI 0.10-5.38]). Fewer events occurred in the maxLCBI4mm <= 400 and PB <=40% quadrant (HR 0.25 [95% CI 0.11-0.50])
UR  - https://dx.doi.org/10.1016/j.ijcard.2022.07.024
ER  -