Hospital readmission with Clostridium difficile infection as a secondary diagnosis is associated with worsened outcomes and greater revenue loss relative to principal diagnosis: A retrospective cohort study. 

 -  2018 
<br/><br/>Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006 
<br/><br/>311). Mean gap between hospital costs and DRG reimbursements was highest in SrCDI (  Recurrent Clostridium difficile infection (rCDI) requiring rehospitalization contributes to poor outcomes, which may differ between patients hospitalized with versus for it.We performed a multicenter retrospective cohort study of rehospitalized adults surviving initial CDI hospitalization. Hospital mortality, length of stay (LOS), 30-day readmission, and mean gap between hospital costs and Diagnosis Related Group (DRG) reimbursement served as outcomes.Among the 25.7% (n = 99,175) survivors requiring rehospitalization, 36,504 (36.8%) had rCDI (14,005 [38.4%] principal diagnosis rCDI [PrCDI]). Compared with non-CDI, PrCDI, and secondary diagnosis rCDI [SrCDI] carried lower risk of death (PrCDI odds ratio [OR] 0.52; 95% confidence interval [CI] 0.46, 0.58; SrCDI OR 0.80; 95% CI 0.75, 0.85) and 30-day readmission (PrCDI OR 0.84; 95% CI 0.80, 0.88; SrCDI OR 0.97; 95% CI 0.94, 1.01), and excess LOS (PrCDI 1.8 days; 95% CI 1.7, 2.0; SrCDI 1.4 days; 95% CI 1.3, 1.5), and costs (PrCDI  
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>0025-7974 
<br/><br/><label>Standard No.: </label>00005792-201809070-00076 [pii] 10.1097/MD.0000000000012212 [doi] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Clostridium Infections/di [Diagnosis]<br/>*Clostridium Infections/th [Therapy]<br/>*Patient Readmission<br/>Adolescent<br/>Adult<br/>Aged<br/>Clostridium Infections/ec [Economics]<br/>Clostridium Infections/mo [Mortality]<br/>Female<br/>Follow-Up Studies<br/>Health Care Costs<br/>Hospital Mortality<br/>Humans<br/>Length of Stay/ec [Economics]<br/>Male<br/>Middle Aged<br/>Patient Readmission/ec [Economics]<br/>Retrospective Studies<br/>United States<br/>Young Adult
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Medicine/Pulmonary-Critical Care
<br/><br/><label>Index Terms--Function: </label><br/>Comparative Study<br/>Journal Article<br/>Multicenter Study<br/>Observational Study