03021nam a22005177a 4500
181108s20192019 xxu||||| |||| 00| 0 eng d
1047-3211
10.1093/cercor/bhy270 [doi]
5144871 [pii]
Ovid MEDLINE(R)
30364937
Precision Inhibitory Stimulation of Individual-Specific Cortical Hubs Disrupts Information Processing in Humans.
Cerebral Cortex. 29(9):3912-3921, 2019 08 14.
Cereb Cortex. 29(9):3912-3921, 2019 08 14.
Cereb Cortex. 2018 Oct 25
Cerebral cortex (New York, N.Y. : 1991)
2019
FY2019
aheadofprint
ppublish
2018-11-09
Cerebral Cortex. 2018 Oct 25
Noninvasive brain stimulation (NIBS) is a promising treatment for psychiatric and neurologic conditions, but outcomes are variable across treated individuals. In principle, precise targeting of individual-specific features of functional brain networks could improve the efficacy of NIBS interventions. Network theory predicts that the role of a node in a network can be inferred from its connections; as such, we hypothesized that targeting individual-specific "hub" brain areas with NIBS should impact cognition more than nonhub brain areas. Here, we first demonstrate that the spatial positioning of hubs is variable across individuals but reproducible within individuals upon repeated imaging. We then tested our hypothesis in healthy individuals using a prospective, within-subject, double-blind design. Inhibition of a hub with continuous theta burst stimulation disrupted information processing during working-memory more than inhibition of a nonhub area, despite targets being separated by only a few centimeters on the right middle frontal gyrus of each subject. Based upon these findings, we conclude that individual-specific brain network features are functionally relevant and could leveraged as stimulation sites in future NIBS interventions.
English
*Cerebral Cortex/ah [Anatomy & Histology]
*Cerebral Cortex/ph [Physiology]
*Memory, Short-Term/ph [Physiology]
*Neural Inhibition/ph [Physiology]
*Transcranial Direct Current Stimulation
Adult
Double-Blind Method
Female
Humans
Male
Neural Pathways/ah [Anatomy & Histology]
Neural Pathways/ph [Physiology]
Prospective Studies
Reproducibility of Results
Young Adult
MedStar National Rehabilitation Network
Journal Article
Turkeltaub, Peter E
Breeden AL, Cherry JBC, Gordon EM, Lynch CJ, Turkeltaub PE, Vaidya CJ
https://dx.doi.org/10.1093/cercor/bhy270
https://dx.doi.org/10.1093/cercor/bhy270
ART
Article
0
0
0
0
Article
authcat
authcat
2018-11-09
0
30364937
30364937
2018-11-09
2018-11-09
ART
3875
3875