TY - BOOK AU - Chia, Stanley TI - Post-approval upper airway stimulation predictors of treatment effectiveness in the ADHERE registry SN - 0903-1936 PY - 2019/// KW - *Electric Stimulation Therapy/is [Instrumentation] KW - *Implantable Neurostimulators KW - *Patient Satisfaction KW - *Product Surveillance, Postmarketing KW - *Sleep Apnea, Obstructive/th [Therapy] KW - Aged KW - Female KW - Germany KW - Humans KW - Logistic Models KW - Male KW - Middle Aged KW - Registries KW - Time Factors KW - Treatment Outcome KW - United States KW - MedStar Washington Hospital Center KW - Otolaryngology KW - Journal Article N1 - Available online from MWHC library: 1994 - present N2 - Copyright (c)ERS 2018; Upper airway stimulation (UAS) has been shown to reduce severity of obstructive sleep apnea (OSA). The aim of this registry was to identify predictors of UAS therapy response in an international multicenter registry. Patients who underwent UAS implantation in the US and Germany were enrolled in an observational registry. Data collected included patient characteristics, apnea-hypopnea index (AHI), Epworth Sleepiness Scale, objective adherence, adverse events, and patient satisfaction measures. Post hoc univariate and multiple logistic regression were performed to evaluate factors associated with treatment success. Between October 2016 and January 2018, 508 participants were enrolled from 14 centers. Median AHI was reduced from 34.0 to 7.0 events.h-1, median ESS reduced from 12 to 7 from baseline to final visit at 12-month post-implant. In post hoc analyses, for each 1-year increase in age, there was a 4% increase in odds of treatment success. For each 1 unit increase in BMI, there was 9% reduced odds of treatment success. In the multivariable model, age persisted in serving as statistically significant predictor of treatment success.In a large multicenter international registry, UAS is an effective treatment option with high patient satisfaction and low adverse events. Increasing age and reduced BMI are predictors of treatment response UR - https://dx.doi.org/10.1183/13993003.01405-2018 ER -