TY  - BOOK
AU  - Grantz, Katherine L
TI  - Trajectories of maternal gestational weight gain and child cognition assessed at 5 years of age in a prospective cohort study
SN  - 0143-005X
PY  - 2016///
KW  - *Child Development
KW  - *Intelligence
KW  - *Prenatal Exposure Delayed Effects
KW  - *Weight Gain
KW  - Child, Preschool
KW  - Cognition
KW  - Female
KW  - Humans
KW  - IN PROCESS -- NOT YET INDEXED
KW  - Pregnancy
KW  - Prospective Studies
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology/Maternal-Fetal Medicine
KW  - Journal Article
N1  - Available online through MWHC library: 1947 - 2005
N2  - BACKGROUND: There has been concern that low gestational weight gain may cause poor fetal neurodevelopment; CONCLUSIONS: Our findings are reassuring that among normal weight women, pregnancy weight gain is not associated with child cognitive development. Further investigation should be conducted in contemporary cohorts that also include obese mothers, who are at the greatest risk for low weight gain; Copyright Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing; METHODS: The association between maternal weight gain and child IQ was examined using serial antenatal weight measurements (median 12) from a prospective cohort of non-obese Scandinavian women (1986-1988). Linear mixed models with piecewise regression were used to estimate participants' (n=552) trimester-specific average rate of weight gain. Linear regression was used to assess the association between weight gain and children's (n=344) full-scale, performance and verbal IQ measured at age 5 using the Wechsler Preschool and Primary Scales of Intelligence-Revised; RESULTS: Children born to mothers who gained below versus within the 2nd trimester 2009 recommendations tended to have lower IQ scores (Full-scale: 106.6 (SD 15.1) vs 110.2 (15.2), p=0.04; verbal: 102.5 (14.3) vs 105.0 (14.9), p=0.10; performance: 109.5 (15.4) vs 113.4 (14.5), p=0.03). After adjustment there were no differences in child IQ by weight gain adequacy (full-scale: betabelow=-1.1 (95% CI -5.1 to 2.9), betaabove=1.5 (-3.8 to 6.8); verbal: betabelow=-0.2 (-3.1 to 2.6), betaabove=1.8 (-3.6 to 7.3); performance betabelow=-1.2 (-4.6 to 2.2), betaabove=1.0 (-4.6 to 6.7)). No differences were observed based on 3rd trimester adequacy. No differences were observed in IQ scores by quintile of weight gain for any trimester, particularly after adjustment for maternal IQ
UR  - https://dx.doi.org/10.1136/jech-2014-205108
ER  -