TY  - BOOK
AU  - Zikusoka, Michelle
TI  - Associations between lipids and subclinical coronary atherosclerosis
SN  - 0269-9370
PY  - 2019///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Union Memorial Hospital
KW  - Cardiology
KW  - Journal Article
N2  - CONCLUSION: The associations between lipids and coronary atherosclerosis tended to be weaker for HIV+ compared to HIV- men, although TC/HDL had the strongest association for both HIV+ and HIV- men. A weaker association between lipid levels and coronary atherosclerosis for HIV+ men may contribute to the decreased discrimination of CVD risk observed in HIV+ individuals; DESIGN: The Multicenter AIDS Cohort Study (MACS) is an observational cohort with a total of 429 HIV+ and 303 HIV- men who had non-contrast cardiac computed tomography (CT) performed to measure coronary artery calcium (CAC) and coronary CT angiography to measure coronary stenosis, coronary plaque presence, and composition; METHODS: We used multivariable adjusted prevalence ratios (PR) to examine the relationship between the standard deviation (SD) difference in each lipid parameter and coronary atherosclerosis; OBJECTIVE: Whether HIV modifies the relationship of serum lipids with coronary atherosclerosis and coronary plaque subtypes is uncertain. We examined the associations between traditional lipids and coronary atherosclerosis among HIV-infected (HIV+) and HIV-uninfected (HIV-) men; RESULTS: Total cholesterol (TC) / HDL-C had the strongest associations with coronary atherosclerosis regardless of HIV status. Overall, lipid parameters were most strongly associated with the presence of mixed plaque, stenosis >50%, and CAC for both HIV+ and HIV- men. HIV+ men had similar, but weaker associations, between lipid parameters and coronary atherosclerosis compared to HIV- men. The strongest association was between the TC/HDL-C and stenosis >50% for both HIV+ [PR 1.25 per SD (95% CI 1.07-1.43)] and HIV- men [PR 1.46 per SD (95% CI 1.08-1.85)]
UR  - https://dx.doi.org/10.1097/QAD.0000000000002151
ER  -