TY - BOOK AU - Colton, Bradley AU - Manning, Maria A TI - Exceptional Response to Systemic Therapy in Advanced Metastatic Gastric Cancer: A Case Report SN - 2168-8184 PY - 2016/// KW - PubMed-not-MEDLINE -- Not indexed KW - MedStar Medical Group KW - Washington Cancer Institute KW - Case Reports N2 - Gastroesophageal adenocarcinomas represent one of the top five most common types of cancer worldwide. Despite significant advancement, it is still not known which first-line chemotherapy option is best matched to an individual patient. The vast advances in molecular biology have led to the discovery of many potential predictive biomarkers, such as HER-2 neu, thymidylate synthase (TS), excision repair cross-complementation group 1 (ERCC1), and topoisomerase-1 (TOPO1). These markers could allow us to select treatment based on an individual's tumor profile, resulting in an improvement of outcome. Our report highlights two patients with metastatic gastric cancer that achieved an exceptional response with traditional therapy and provides insights into the future perspectives of molecular profile-directed chemotherapy UR - https://dx.doi.org/10.7759/cureus.457 ER -