TY  - BOOK
AU  - Mattar, Mark C
AU  - Tabbaa, Obada
TI  - Safety and efficacy of fecal microbiota transplant in 9 critically ill patients with severe and complicated Clostridium difficile infection with impending colectomy
SN  - 1751-2972
PY  - 2019///
KW  - *Clostridium difficile
KW  - *Colectomy
KW  - *Enterocolitis, Pseudomembranous/th [Therapy]
KW  - *Fecal Microbiota Transplantation/mt [Methods]
KW  - *Preoperative Care/mt [Methods]
KW  - Aged
KW  - Critical Illness/th [Therapy]
KW  - Enterocolitis, Pseudomembranous/mi [Microbiology]
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Recurrence
KW  - Treatment Outcome
KW  - MedStar Washington Hospital Center
KW  - Medicine/Gastroenterology
KW  - Journal Article
N2  - CONCLUSION: Our success with FMT in fulminant CDI shows that this therapeutic modality is a promising alternative to a colectomy and could be a potential bowel-saving intervention; Copyright (c) 2019 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd; METHODS: This was a 2-center study of 9 patients who met the criteria for severe and complicated CDI and had an impending colectomy. All 9 patients had failed conventional antibiotic therapy and were deemed too unstable to undergo a colectomy. Hence, FMT was considered to be the next step in managing their condition; OBJECTIVE: Significant data support the efficacy and safety of fecal microbiota transplant (FMT) in recurrent Clostridium difficile infection (CDI). The objective of our study was to determine the success rate of FMT in patients diagnosed with severe and complicated CDI with impending colectomy in the intensive care setting; RESULTS: Following FMT there was marked improvement in the patients' clinical status, with the resolution of diarrhea, reduced requirement for vasopressor, and the reduction in abdominal distention and pain. The primary cure rate of our study after a single round of FMT was 78% (7/9). Of the 9 patients 8 (88.88%) avoided a colectomy during the same hospital admission. the CDI-related death rate was 12.5% (1/9) and that of non-CDI was 12.5% (1/9)
UR  - https://dx.doi.org/10.1111/1751-2980.12750
ER  -