TY  - BOOK
AU  - Benson, Richard T
AU  - Hsia, Amie W
TI  - Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study
SN  - 2328-9503
PY  - 2019///
KW  - *Brain Ischemia/ge [Genetics]
KW  - *Brain/pa [Pathology]
KW  - *Cerebrovascular Circulation/ph [Physiology]
KW  - *Stroke/ge [Genetics]
KW  - Aged
KW  - Aged, 80 and over
KW  - Brain Ischemia/di [Diagnosis]
KW  - Brain/me [Metabolism]
KW  - Diffusion Magnetic Resonance Imaging
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Research Design
KW  - Stroke/di [Diagnosis]
KW  - MedStar Washington Hospital Center
KW  - Neurology
KW  - Journal Article
N2  - We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score -2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition
UR  - https://dx.doi.org/10.1002/acn3.757
ER  -